T-cell specific immunosuppression by prodigiosin isolated from Serratia marcescens

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Title
T-cell specific immunosuppression by prodigiosin isolated from Serratia marcescens
Author(s)
Sang Bae Han; Hwan Mook Kim; Young Hee Kim; Chang Woo Lee; Eun Sook Son; Kwang Hee Son; Sung Uk Kim; Young Kook Kim
Bibliographic Citation
International Journal of Immunopharmacology, vol. 20, no. 1-3, pp. 1-13
Publication Year
1998
Abstract
Prodigiosin was isolated from the culture broth of Serratia marcescens B-1231. This compound inhibited the T-cell mediated immune responses such as concanavalin-A induced proliferation, mixed lymphocyte response, local graft vs host reaction and T-dependent antibody response at non-toxic concentrations. However, prodigiosin did not affect B-cell mediated immune functions such as lipopolysaccharide-induced proliferation and -activated polyclonal antibody production at the same concentrations. Prodigiosin did not cause death in vitro to lymphocytes at effective concentrations (< 100 nM) and also did not show toxicity in vivo to lymphoid organs at effective dosages (10 and 30 mg/kg). The pharmacological potencies were comparable to the activities of other T-cell specific immunosuppressants such as cyclosporin A and FK-506. In conclusion, it might be suggested that prodigiosin could be used as an immunosuppressant in clinical and immunological studies.
Keyword
ProdigiosinImmunosuppressantT-cell mediated immune functionsB-cell mediated immune functions
ISSN
0192-0561
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0192-0561(97)00062-3
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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