DC Field | Value | Language |
---|---|---|
dc.contributor.author | Won Keun Oh | - |
dc.contributor.author | Hyun Sun Lee | - |
dc.contributor.author | Bo Yeon Kim | - |
dc.contributor.author | Hye Kyung Chang | - |
dc.contributor.author | Yong Hae Kim | - |
dc.contributor.author | Jean Wandji | - |
dc.contributor.author | J Tanyl Mbafor | - |
dc.contributor.author | Tanee Fomum | - |
dc.contributor.author | Jong Seog Ahn | - |
dc.date.accessioned | 2017-04-19T08:55:22Z | - |
dc.date.available | 2017-04-19T08:55:22Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/4409 | - |
dc.description.abstract | Auriculatin and 8-prenylluteone were isolated from Erythrina senegalensis (Leguminosae) as inhibitors of phospholipase C (PLC) and phosphoinositides (PI)-turnover in PLC-γ1 overexpressing NIH3T3 fibroblasts (NIH3T3γ1). Auriculatin (1) and 8-prenylluteone (2) showed inhibitory activity with an IC50 value of 20 μM on PLC in vitro as well as the formation of inositol phosphates in platelet-derived growth factor (PDGF)-stimulated NIH3T3γ1 cells. They also showed a moderate cytotoxicity against several human tumour cell lines with an IC50 of 9.0-20 μm, i.e. PC-3 (prostate), NCI-H226 (lung), CRL1579 (melanoma) in vitro. | - |
dc.publisher | Wiley | - |
dc.title | Inhibition of phospholipase C activity by auriculatin and 8-prenylluteone isolated from Erythrina senegalensis | - |
dc.title.alternative | Inhibition of phospholipase C activity by auriculatin and 8-prenylluteone isolated from Erythrina senegalensis | - |
dc.type | Article | - |
dc.citation.title | Phytotherapy Research | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 12 | - |
dc.citation.startPage | 9 | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | Won Keun Oh | - |
dc.contributor.affiliatedAuthor | Hyun Sun Lee | - |
dc.contributor.affiliatedAuthor | Bo Yeon Kim | - |
dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
dc.contributor.alternativeName | 오원근 | - |
dc.contributor.alternativeName | 이현선 | - |
dc.contributor.alternativeName | 김보연 | - |
dc.contributor.alternativeName | 장혜경 | - |
dc.contributor.alternativeName | 김용해 | - |
dc.contributor.alternativeName | Wandji | - |
dc.contributor.alternativeName | Mbafor | - |
dc.contributor.alternativeName | Fomum | - |
dc.contributor.alternativeName | 안종석 | - |
dc.identifier.bibliographicCitation | Phytotherapy Research, vol. 12, no. 1, pp. 9-12 | - |
dc.identifier.doi | 10.1002/(sici)1099-1573(19980201)12:1<9::aid-ptr175>3.0.co;2-%23 | - |
dc.subject.keyword | phospholipase C | - |
dc.subject.keyword | total inositol phosphates | - |
dc.subject.keyword | auriculatin | - |
dc.subject.keyword | 8-prenylluteone | - |
dc.subject.keyword | Erythrina senegalensis | - |
dc.subject.keyword | Leguminosae | - |
dc.subject.local | phospholipase C | - |
dc.subject.local | Phospholipase C | - |
dc.subject.local | total inositol phosphates | - |
dc.subject.local | auriculatin | - |
dc.subject.local | 8-prenylluteone | - |
dc.subject.local | Erythrina senegalensis | - |
dc.subject.local | erythrina senegalensis | - |
dc.subject.local | Leguminosae | - |
dc.subject.local | leguminosae | - |
dc.description.journalClass | Y | - |
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