Inhibition of angiotensin II receptor binding by quinolone alkaloids from Evodia rutaecarpa

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Title
Inhibition of angiotensin II receptor binding by quinolone alkaloids from Evodia rutaecarpa
Author(s)
Hyun Sun Lee; Won Keun Oh; Hee Cheol Choi; Jun Won Lee; Dae Ook Kang; Chan Sun Park; Tae Ick MheenJong Seog Ahn
Bibliographic Citation
Phytotherapy Research, vol. 12, no. 3, pp. 212-214
Publication Year
1998
Abstract
A biologically monitored fractionation of methanol extracts of the fruit of Evodia rutaecarpa led to the isolation of quinolone alkaloids, evocarpin (1), 1-methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2) and 1- methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (3) as blockers of angiotensin II receptor binding with IC50 values of 43.4 μM, 34. μM and 48.2 μM, respectively.
Keyword
angiotensin II receptor bindingquinolone alkaloidEvodia rutaecarpaRutaceae
ISSN
0951-418X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/(SICI)1099-1573(199805)12:3<212::AID-PTR216>3.0.CO;2-5
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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