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- Title
- Inhibition of angiotensin II receptor binding by quinolone alkaloids from Evodia rutaecarpa
- Author(s)
- Hyun Sun Lee; Won Keun Oh; Hee Cheol Choi; Jun Won Lee; Dae Ook Kang; Chan Sun Park; Tae Ick Mheen; Jong Seog Ahn
- Bibliographic Citation
- Phytotherapy Research, vol. 12, no. 3, pp. 212-214
- Publication Year
- 1998
- Abstract
- A biologically monitored fractionation of methanol extracts of the fruit of Evodia rutaecarpa led to the isolation of quinolone alkaloids, evocarpin (1), 1-methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2) and 1- methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (3) as blockers of angiotensin II receptor binding with IC50 values of 43.4 μM, 34. μM and 48.2 μM, respectively.
- Keyword
- angiotensin II receptor bindingquinolone alkaloidEvodia rutaecarpaRutaceae
- ISSN
- 0951-418X
- Publisher
- Wiley
- Full Text Link
- http://dx.doi.org/10.1002/(SICI)1099-1573(199805)12:3<212::AID-PTR216>3.0.CO;2-5
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
- Files in This Item:
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