Actinomycin D,C₂ and VII, inhibitors of Grb2-Shc interaction produced by Streptomyces

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Title
Actinomycin D,C₂ and VII, inhibitors of Grb2-Shc interaction produced by Streptomyces
Author(s)
Ji Youn Nam; H K Kim; Kwang Hee Son; Sung Uk Kim; Byoung-Mog Kwon; Mi Young Han; Y J Chung; Song Hae Bok
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 8, no. 15, pp. 2001-2001
Publication Year
1998
Abstract
Actinomycin D, C2 and VII, cyclic peptides, inhibited Grb2 SH2 domain association (IC50 5-7 μM) with a phosphotyrosine containing peptide derived from the Shc protein (pTyr317). Actinomycins are the first examples of nonphosphorylated natural ligands of SH2 domain.
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0960-894X(98)00345-X
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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