Synthesis and In vitro cytotoxicity of cinnamaldehydes to human solid tumor cells

Cited 60 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorSeung Ho Lee-
dc.contributor.authorSang Un Choi-
dc.contributor.authorSung Hee Park-
dc.contributor.authorChong Ock Lee-
dc.contributor.authorYoung Kwon Cho-
dc.contributor.authorNack Do Sung-
dc.contributor.authorSong Hae Bok-
dc.date.accessioned2017-04-19T08:55:23Z-
dc.date.available2017-04-19T08:55:23Z-
dc.date.issued1998-
dc.identifier.issn02536269-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4415-
dc.description.abstractCinnamaldehydes and related compounds were synthesized from various cinnamic acids based on the 2′-hydroxycinnamaldehyde isolated from the bark of Cinnamomum cassia Blume. The cytotoxicity to human solid tumor cells such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT15 were measured. Cinnamic acid, cinnamates and cinnamyl alcohols did not show any cytotoxicity against the human tumor cells. Cinnamaldehydes and realted compounds were resistant to A549 cell line up to 15 μg/ml. In contrast, HCT15 and SK-MEL-2 cells were much sensitive to these cinnamaldehyde analogues which showed ED50 values 0.63∼8.1 μg/ml. Cytotoxicity of the saturated aldehydes was much weak compared to their unsaturated aldehydes. From these studies, it was found that the key functional group of the cinnamaldehyde-related compounds in the antitumor activity is the propenal group.-
dc.publisherPharmaceutical Soc Korea-
dc.titleSynthesis and In vitro cytotoxicity of cinnamaldehydes to human solid tumor cells-
dc.title.alternativeSynthesis and In vitro cytotoxicity of cinnamaldehydes to human solid tumor cells-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number2-
dc.citation.endPage152-
dc.citation.startPage147-
dc.citation.volume21-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName이승호-
dc.contributor.alternativeName최상은-
dc.contributor.alternativeName박성희-
dc.contributor.alternativeName이종옥-
dc.contributor.alternativeName조영권-
dc.contributor.alternativeName성낙도-
dc.contributor.alternativeName복성해-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 21, no. 2, pp. 147-152-
dc.identifier.doi10.1007/BF02974019-
dc.subject.keywordCinnamaldehyde-
dc.subject.keywordHuman tumor cell-
dc.subject.keywordCytotoxicity-
dc.subject.keywordCinnamomum cassia-
dc.subject.localCinnamaldehyde-
dc.subject.localHuman tumor cell-
dc.subject.localCytotoxicity-
dc.subject.localCinnamomum cassia-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.