Triuncleotide repeat polymorphisms of SBMA locus in Koreans, Chinese, Japanese and Caucasoids

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Title
Triuncleotide repeat polymorphisms of SBMA locus in Koreans, Chinese, Japanese and Caucasoids
Author(s)
Su Bok Lee; Jun Goto; Ichiro Kanazawa; Yong Ha Park; Momoki Hirai
Bibliographic Citation
Korean Journal of Physical Anthropology, vol. 10, no. 2, pp. 217-223
Publication Year
1997
Abstract
SBMA (Spinal bulbar muscular atrophy) is a neurodegenerative disease and the extension of the triplet repeat DNA tracks on this SBMA locus is related with the onset of the genetic disease In this study we investigated the PCR-based STRs(Short Tandem Repeats) polymorphisms for the SBMA locus in healthy South Koreans, Chinese Japanese and Caucasoids As the result, we could detect the significant differences among the four populations And the allele distribution of each population was single modal The CAG alleles of South Koreans and Chinese showed very similar distributions each other, but the distribution of CAG alleles in Japanese population was clsoer to the one of Caucasoids The T test after doing the F test also detected the significant difference reflecting this similarity between Japanese and Caucasoids
Keyword
KoreanChineseJapaneseCaucasoidSBMATrinucleotide repeat polymorphism
ISSN
I000-0086
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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