Multidrug-resistance reversing activity of medicinal plants = 약용 식물의 암세포 다제내성 조절 활성 검색

Abstract

Methanol extracts from 450 plants were screened for multidrug-resistance reversing activity using drug sensitive KB-3-1 and multidrug-resistance KB- V1 cells. Among them, the extracts of Cynanchum wilfordii. Torilis japonica. Celastrus orbiculatus. Melia toosendan and Terminalia chebula strongly potentiated vinblastine cytotoxicity in KB-V1 cells. But their cytotoxicities to both sensitive KB-3-1 and resistant KB-V1 cells were in the same order of magnitude. These results indicate that the above samples would contain the active principles which do not exert their activity solely by cytotoxicity.