Production of 1-deoxynojirimycin by Streptomyces sp. SID 9135

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Production of 1-deoxynojirimycin by Streptomyces sp. SID 9135
Paek, Nam Soo; Dae Jung Kang; Yong Jin Choi; Jung Joon Lee; Tae Han Kim; Kee Won Kim
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 7, no. 4, pp. 262-266
Publication Year
To increase the high production of 1-deoxynojirimycin (DNJ) from Streptomyces sp. SID9135, the effect of various carbon sources, nitrogen sources, cationic metal ions, the initial pH of the medium, and agitation speed were investigated. The most effective carbon and nitrogen sources were found to be lactose 2.5% (w/v) and soybean meal 2.0% (w/v), respectively. None of the cationic metal ions examined had any detectable stimulating effect on DNJ production except Fe+2 ion. The initial optimum pH for DNJ production ranged from 6-8 and agitation speed was most effective at 400 rpm. In the jar fermentor experiments under optimal culture conditions, the accumulation of DNJ reached about 640 μg/ml after 5 days of cultivation and the level remained the same for a further two days.
α-glucosidase inhibitor1-deoxynojirimycinStreptomyces sp. SID9135
Korea Soc-Assoc-Inst
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