Magnone A and B, novel Anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii

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dc.contributor.authorKeun Young Jung-
dc.contributor.authorDong Seon Kim-
dc.contributor.authorSei Ryang Oh-
dc.contributor.authorSi Hyung Park-
dc.contributor.authorIm Seon Lee-
dc.contributor.authorJung Joon Lee-
dc.contributor.authorDong Hyuk Shin-
dc.contributor.authorHyeong Kyu Lee-
dc.date.accessioned2017-04-19T08:55:29Z-
dc.date.available2017-04-19T08:55:29Z-
dc.date.issued1998-
dc.identifier.issn0163-3864-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4466-
dc.description.abstractIn a search for platelet-activating-factor (PAF) antagonists, two new lignan compounds were isolated from the Chinese crude drug shin-i, the flower buds of Magnolia fargesii. Their structures were elucidated as (2S,3R,4R)- tetrahydro-2-(3,4-dimethoxyphenyl)-4-(3,4-dimethoxybenzoyl)-3- (hydroxymethyl)furan (magnone A, 1) and (2S,3R,4R)-tetrahydro-2-(3,4,5- trimethoxyphenyl)-4-(3,4-dimethoxybenzoyl)-3-(hydroxymethyl)furan (magnone B, 2). Magnones A and B showed antagonistic activity against PAF in the [3H]PAF receptor binding assay with the IC50 values of 3.8 x 10-5 M and 2.7 x 10-5 M, respectively.-
dc.publisherAmer Chem Soc-
dc.titleMagnone A and B, novel Anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii-
dc.title.alternativeMagnone A and B, novel Anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number0-
dc.citation.endPage811-
dc.citation.startPage808-
dc.citation.volume61-
dc.contributor.affiliatedAuthorKeun Young Jung-
dc.contributor.affiliatedAuthorDong Seon Kim-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorSi Hyung Park-
dc.contributor.affiliatedAuthorIm Seon Lee-
dc.contributor.affiliatedAuthorJung Joon Lee-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName정근영-
dc.contributor.alternativeName김동선-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName박시형-
dc.contributor.alternativeName이임선-
dc.contributor.alternativeName이정준-
dc.contributor.alternativeName신동혁-
dc.contributor.alternativeName이형규-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 61, pp. 808-811-
dc.identifier.doi10.1021/np970445+-
dc.description.journalClassY-
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