House dust mite-induced sensitivity in mice

Cited 14 time in scopus
Metadata Downloads
Title
House dust mite-induced sensitivity in mice
Author(s)
In Seong Choe
Bibliographic Citation
Journal of Allergy and Clinical Immunology, vol. 101, no. 1, pp. 51-59
Publication Year
1998
Abstract
Sensitivity induced by house dust mite (HDM) extract in mice was investigated in this study. Sensitized B10.RIII mice (H-2(r) background) had T-cell proliferative responses to HDM extract in vitro and an HDM-specific IgE response. When mice were immunized by injection and intranasal inhalation with HDM extract, a histologic study showed eosinophils and mononuclear cell infiltration in the lung tissue and bronchial wall. Tcrαβ-positive cells were also found in the cell infiltration area of the lung lesions. In the control mice that were immunized by injection or intranasal inhalation (but not both), we did not observe cell accumulation in the lung tissue or in the bronchial wall. Epitope studies suggest that T cells recognize multiple epitopes. Molecular analysis of these HDM-specific T-cell hybridoma clones suggest that T-cell receptor use is restricted to members of the Vα 8 and Vβ 6 subfamilies.
Keyword
HDM-induced sensitivityT-cell receptor useDer p 1T-cell epitopeseosinophilic cellsmononuclear-cell infiltration
ISSN
I000-0097
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0091-6749(98)70193-9
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.