Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones

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Title
Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones
Author(s)
S H Jung; H S Lee; J S Song; Hwan Mook Kim; Sang Bae Han; Chang Woo Lee; M S Lee; D R Choi; J A Lee; Y H Chung; S J Yoon; Eun Yi Moon; H S Hwang; S K Seong; D K Lee
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 8, no. 12, pp. 1547-1550
Publication Year
1998
Abstract
Novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 3 synthesized show highly potent and broad cytotoxicities. Among them compound 3b (DW2143) exhibits much more potent cytotoxicities than doxorubicin and highly effective antitumor activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0960-894X(98)00261-3
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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