Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones
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- Title
- Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones
- Author(s)
- S H Jung; H S Lee; J S Song; Hwan Mook Kim; Sang Bae Han; Chang Woo Lee; M S Lee; D R Choi; J A Lee; Y H Chung; S J Yoon; Eun Yi Moon; H S Hwang; S K Seong; D K Lee
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 8, no. 12, pp. 1547-1550
- Publication Year
- 1998
- Abstract
- Novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 3 synthesized show highly potent and broad cytotoxicities. Among them compound 3b (DW2143) exhibits much more potent cytotoxicities than doxorubicin and highly effective antitumor activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.
- ISSN
- 0960-894X
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/S0960-894X(98)00261-3
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
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