Phospholipase Cγ1 inhibitory principles from the sarcotestas of Ginkgo biloba

Cited 42 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorJi Suk Lee-
dc.contributor.authorYou Sun Cho-
dc.contributor.authorEun Jung Park-
dc.contributor.authorJin Woong Kim-
dc.contributor.authorWon Keun Oh-
dc.contributor.authorHyun Sun Lee-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2017-04-19T08:55:36Z-
dc.date.available2017-04-19T08:55:36Z-
dc.date.issued1998-
dc.identifier.issn0163-3864-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4513-
dc.description.abstractTen phenolic compounds were isolated from the CHCl3 extract of Ginkgo biloba sarcotestas (Ginkgoaceae) as a new class of phosphatidylinositol- specific phospholipase Cγ1 (PI-PLCγ1) inhibitors. The substances without the long chain were ineffective: On the other hand, the activities of these compounds were dramatically decreased by acetylation of aromatic hydroxyl groups of cardanol, phenolic acid, and bilobol and by methylation of the aromatic carboxyl group of phenolic acid. The unsaturated long chain as well as the aromatic hydroxyl and carboxyl groups might play a key role for the PI-PLCγ1 inhibitory activity. These compounds also inhibited the growth of a number of human cancer cell lines, but were less cytotoxic against a human normal colon cell line.-
dc.publisherAmer Chem Soc-
dc.titlePhospholipase Cγ1 inhibitory principles from the sarcotestas of Ginkgo biloba-
dc.title.alternativePhospholipase Cγ1 inhibitory principles from the sarcotestas of Ginkgo biloba-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number7-
dc.citation.endPage871-
dc.citation.startPage867-
dc.citation.volume61-
dc.contributor.affiliatedAuthorWon Keun Oh-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName이지숙-
dc.contributor.alternativeName조유선-
dc.contributor.alternativeName박은정-
dc.contributor.alternativeName김진웅-
dc.contributor.alternativeName오원근-
dc.contributor.alternativeName이현선-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 61, no. 7, pp. 867-871-
dc.identifier.doi10.1021/np970367q-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.