DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jae Yoon Leem | - |
dc.contributor.author | Ho Yong Park | - |
dc.contributor.author | Hidesuke Fukazawa | - |
dc.contributor.author | Yoshimasa Uehara | - |
dc.contributor.author | Shunji Natori | - |
dc.date.accessioned | 2017-04-19T08:55:38Z | - |
dc.date.available | 2017-04-19T08:55:38Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/4525 | - |
dc.description.abstract | We examined the inhibitory effects of N-β-alanyl-5-S-glutathionyl-3,4- dihydroxyphenylalanine (5-S-GAD), a novel antibacterial substance from the immunized adult Sarcophaga peregrina (flesh fly), on protein phosphorylation using immune complexes of protein tyrosine kinases (PTKs) with anti-PTKs monoclonal antibody. We found that 5-S-GAD directly inhibited not only tyrosine phosphorylation of PTK p60(v-src), but also tyrosine phosphorylation of PTK p210(BCR-ABL). The inhibitory potency of 5-S-GAD was comparable to that of radicicol and herbimycin A of PTK inhibitor. | - |
dc.publisher | Pharmaceutical Soc Japan | - |
dc.title | Inhibitory effects of 5-S-GAD on phosphorylation of V-SRC and BCR-ABL tyrosine kinase | - |
dc.title.alternative | Inhibitory effects of 5-S-GAD on phosphorylation of V-SRC and BCR-ABL tyrosine kinase | - |
dc.type | Article | - |
dc.citation.title | Biological & Pharmaceutical Bulletin | - |
dc.citation.number | 7 | - |
dc.citation.endPage | 785 | - |
dc.citation.startPage | 784 | - |
dc.citation.volume | 21 | - |
dc.contributor.affiliatedAuthor | Jae Yoon Leem | - |
dc.contributor.affiliatedAuthor | Ho Yong Park | - |
dc.contributor.alternativeName | 임재윤 | - |
dc.contributor.alternativeName | 박호용 | - |
dc.contributor.alternativeName | Fukazawa | - |
dc.contributor.alternativeName | Uehara | - |
dc.contributor.alternativeName | Natori | - |
dc.identifier.bibliographicCitation | Biological & Pharmaceutical Bulletin, vol. 21, no. 7, pp. 784-785 | - |
dc.identifier.doi | 10.1248/bpb.21.784 | - |
dc.subject.keyword | 5-S-GAD | - |
dc.subject.keyword | antibacterial substance | - |
dc.subject.keyword | insect immunity | - |
dc.subject.keyword | inhibition of PTKs | - |
dc.subject.keyword | P60(v-src) | - |
dc.subject.keyword | P210(BCR-ABL) | - |
dc.subject.local | 5-S-GAD | - |
dc.subject.local | antibacterial substance | - |
dc.subject.local | Antibacterial substance | - |
dc.subject.local | Insect immunity | - |
dc.subject.local | insect immunity | - |
dc.subject.local | inhibition of PTKs | - |
dc.subject.local | P60(v-src) | - |
dc.subject.local | P210(BCR-ABL) | - |
dc.description.journalClass | Y | - |
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