Inhibitory effects of 5-S-GAD on phosphorylation of V-SRC and BCR-ABL tyrosine kinase

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dc.contributor.authorJae Yoon Leem-
dc.contributor.authorHo Yong Park-
dc.contributor.authorHidesuke Fukazawa-
dc.contributor.authorYoshimasa Uehara-
dc.contributor.authorShunji Natori-
dc.date.accessioned2017-04-19T08:55:38Z-
dc.date.available2017-04-19T08:55:38Z-
dc.date.issued1998-
dc.identifier.issn0918-6158-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4525-
dc.description.abstractWe examined the inhibitory effects of N-β-alanyl-5-S-glutathionyl-3,4- dihydroxyphenylalanine (5-S-GAD), a novel antibacterial substance from the immunized adult Sarcophaga peregrina (flesh fly), on protein phosphorylation using immune complexes of protein tyrosine kinases (PTKs) with anti-PTKs monoclonal antibody. We found that 5-S-GAD directly inhibited not only tyrosine phosphorylation of PTK p60(v-src), but also tyrosine phosphorylation of PTK p210(BCR-ABL). The inhibitory potency of 5-S-GAD was comparable to that of radicicol and herbimycin A of PTK inhibitor.-
dc.publisherPharmaceutical Soc Japan-
dc.titleInhibitory effects of 5-S-GAD on phosphorylation of V-SRC and BCR-ABL tyrosine kinase-
dc.title.alternativeInhibitory effects of 5-S-GAD on phosphorylation of V-SRC and BCR-ABL tyrosine kinase-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number7-
dc.citation.endPage785-
dc.citation.startPage784-
dc.citation.volume21-
dc.contributor.affiliatedAuthorJae Yoon Leem-
dc.contributor.affiliatedAuthorHo Yong Park-
dc.contributor.alternativeName임재윤-
dc.contributor.alternativeName박호용-
dc.contributor.alternativeNameFukazawa-
dc.contributor.alternativeNameUehara-
dc.contributor.alternativeNameNatori-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 21, no. 7, pp. 784-785-
dc.identifier.doi10.1248/bpb.21.784-
dc.subject.keyword5-S-GAD-
dc.subject.keywordantibacterial substance-
dc.subject.keywordinsect immunity-
dc.subject.keywordinhibition of PTKs-
dc.subject.keywordP60(v-src)-
dc.subject.keywordP210(BCR-ABL)-
dc.subject.local5-S-GAD-
dc.subject.localantibacterial substance-
dc.subject.localAntibacterial substance-
dc.subject.localInsect immunity-
dc.subject.localinsect immunity-
dc.subject.localinhibition of PTKs-
dc.subject.localP60(v-src)-
dc.subject.localP210(BCR-ABL)-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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