Production of recombinant hirudin in Hansenula polymorpha : variation of gene expression level depends on methanol oxidase and fermentation strategies
Cited 10 time in 
Metadata Downloads
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chul Ho Kim | - |
| dc.contributor.author | H W Seo | - |
| dc.contributor.author | H Y Kim | - |
| dc.contributor.author | Jung Hoon Sohn | - |
| dc.contributor.author | Eui Sung Choi | - |
| dc.contributor.author | Sang Ki Rhee | - |
| dc.date.accessioned | 2017-04-19T08:55:38Z | - |
| dc.date.available | 2017-04-19T08:55:38Z | - |
| dc.date.issued | 1998 | - |
| dc.identifier.issn | 0169-4146 | - |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/4527 | - |
| dc.description.abstract | Various recombinant Hansenula polymorpha strains were developed and compared for their level of expression of the anticoagulant hirudin. H. polymorpha DL1-57 harboring an autonomously replicating sequence, HARS36, efficiently expressed the gene for recombinant hirudin. The effect of methanol oxidase (MOX) on the expression of the hirudin gene in H. polymorpha DL1-57 was studied, and the fermentation strategies coupled with the MOX activity and an antioxidant, tocopherol, were also examined. | - |
| dc.publisher | Springer | - |
| dc.title | Production of recombinant hirudin in Hansenula polymorpha : variation of gene expression level depends on methanol oxidase and fermentation strategies | - |
| dc.title.alternative | Production of recombinant hirudin in Hansenula polymorpha : variation of gene expression level depends on methanol oxidase and fermentation strategies | - |
| dc.type | Article | - |
| dc.citation.title | Journal of Industrial Microbiology & Biotechnology | - |
| dc.citation.number | 0 | - |
| dc.citation.endPage | 5 | - |
| dc.citation.startPage | 1 | - |
| dc.citation.volume | 21 | - |
| dc.contributor.affiliatedAuthor | Chul Ho Kim | - |
| dc.contributor.affiliatedAuthor | H W Seo | - |
| dc.contributor.affiliatedAuthor | H Y Kim | - |
| dc.contributor.affiliatedAuthor | Jung Hoon Sohn | - |
| dc.contributor.affiliatedAuthor | Eui Sung Choi | - |
| dc.contributor.affiliatedAuthor | Sang Ki Rhee | - |
| dc.contributor.alternativeName | 김철호 | - |
| dc.contributor.alternativeName | 서형원 | - |
| dc.contributor.alternativeName | 김화영 | - |
| dc.contributor.alternativeName | 손정훈 | - |
| dc.contributor.alternativeName | 최의성 | - |
| dc.contributor.alternativeName | 이상기 | - |
| dc.identifier.bibliographicCitation | Journal of Industrial Microbiology & Biotechnology, vol. 21, pp. 1-5 | - |
| dc.identifier.doi | 10.1038/sj.jim.2900545 | - |
| dc.subject.keyword | hirudin | - |
| dc.subject.keyword | Hansenula polymorpha | - |
| dc.subject.keyword | methylotrophic yeast | - |
| dc.subject.keyword | methanol oxidase | - |
| dc.subject.keyword | autonomously replicating sequence | - |
| dc.subject.local | Hirudin | - |
| dc.subject.local | hirudin | - |
| dc.subject.local | Hansenula polymorpha | - |
| dc.subject.local | Hansenula polymorpha (Pichia angusta) | - |
| dc.subject.local | Hansenulapolymorpha | - |
| dc.subject.local | hansenula polymorpha | - |
| dc.subject.local | methylotrophic yeast | - |
| dc.subject.local | Methylotrophic yeast | - |
| dc.subject.local | methanol oxidase | - |
| dc.subject.local | autonomously replicating sequence | - |
| dc.description.journalClass | Y | - |
- Appears in Collections:
- Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
Synthetic Biology and Bioengineering Research Institute > Synthetic Biology Research Center > 1. Journal Articles
Division of Bio Technology Innovation > BioProcess Engineering Center > 1. Journal Articles
- Files in This Item:
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.