Effects of acanthoic acid on TNF-α gene expression and haptoglobin synthesis

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Title
Effects of acanthoic acid on TNF-α gene expression and haptoglobin synthesis
Author(s)
Hyung Sik Kang; H K Song; Jung Joon Lee; Kwang Ho Pyun; In Pyo Choi
Bibliographic Citation
Mediators of Inflammation, vol. 7, pp. 257-259
Publication Year
1998
Abstract
Tumour necrosis factor-α (TNF-α) is a major proinflammatory cytokine inducing the synthesis and release of many inflammatory mediators. It is involved in immune regulation, autoimmune diseases, and inflammation. Our previous study demonstrated that acanthoic acid, (-)-pimara-9(11), 15-dien- 19-oic acid, a pimaradiene diterpene isolated from Acanthopanax koreanum, inhibited TNF-α production. To extend our understanding of inhibitory effects of acanthoic acid on TNF-α production, its effects on TNF-α gene expression was tested. Based on the results from RT-PCR and promoter analysis of TNF-α, it was found that acanthoic acid suppressed TNF-α gene expression. But the same concentration of acanthoic acid had no effect on IL- 6 gene expression. Haptoglobin is an acute phase protein which is induced by TNF-α. When liver cells were treated with acanthoic acid, haptoglobin synthesis was blocked by acanthoic acid. These data confirmed that acanthoic acid inhibited gene expression and biological function of TNF-α.
Keyword
Acanthoic acidHaptoglobinTNF-α
ISSN
0962-9351
Publisher
Hindawi Ltd
DOI
http://dx.doi.org/10.1080/09629359890938
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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