Biotransformation of milbemycin D to milbemycin G by Streptomyces lividans conferring avermectin O-methyltransferase activity

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Title
Biotransformation of milbemycin D to milbemycin G by Streptomyces lividans conferring avermectin O-methyltransferase activity
Author(s)
Young Soo Hong; Bang Yeon Hwang; Hang Sub Kim; Jeong Hyung Lee; Kyu Won Kim; Jung Joon Lee
Bibliographic Citation
Biotechnology Letters, vol. 20, no. 10, pp. 991-995
Publication Year
1998
Abstract
Avermectin O-methyltransferase gene was cloned from a cosmid clone covering the first module of polyketide synthase gene cluster of avermectin biosynthesis. Streptomyces lividans transformed with a DNA fragment containing avermectin O-methyltransferase gene efficiently convert milbemycin D to milbemycin G, indicating that biosynthetic genes of milbemycin and avermectin might complement each other.
Keyword
BiotransformationAvermectinMilbemycinO-methyltransferase
ISSN
0141-5492
Publisher
Springer
DOI
http://dx.doi.org/10.1023/A:1005401229007
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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