Chaetoglobosin A, an inhibitor of Bleb formation on K562 cells induced by phorbol 12,13-dibutyrate

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dc.contributor.authorHack Ryong Ko-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorSoon Cheol Ahn-
dc.contributor.authorWon Keun Oh-
dc.contributor.authorJin Hee Kim-
dc.contributor.authorHyun Sun Lee-
dc.contributor.authorHwan Mook Kim-
dc.contributor.authorSang Bae Han-
dc.contributor.authorTae Ick Mheen-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2017-04-19T08:55:41Z-
dc.date.available2017-04-19T08:55:41Z-
dc.date.issued1998-
dc.identifier.issn10177825-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4548-
dc.description.abstractIn the course of screening for the substances suppressing bleb formation of K562 cell induced by phorbol 12,13-dibutyrate (PDBu), an inhibitor, chaetoglobosin A (CgA) was isolated from a cultured broth of unidentified fungus. CgA showed a strong inhibitory activity with the IC50 value of 60 pM against bleb formation on K562 cells induced by PDBu, but it did not inhibit the activity of protein kinase C (PKC) in vitro. The inhibitory activity of CgA might be due to the modulation of actin filaments on the cell membrane. CgA exhibited strong cytotoxicity against various human cancer cell lines.-
dc.publisherSouth Korea-
dc.titleChaetoglobosin A, an inhibitor of Bleb formation on K562 cells induced by phorbol 12,13-dibutyrate-
dc.title.alternativeChaetoglobosin A, an inhibitor of Bleb formation on K562 cells induced by phorbol 12,13-dibutyrate-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number6-
dc.citation.endPage709-
dc.citation.startPage705-
dc.citation.volume8-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName고학룡-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName안순철-
dc.contributor.alternativeName오원근-
dc.contributor.alternativeName김진희-
dc.contributor.alternativeName이현선-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName한상배-
dc.contributor.alternativeName민태익-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 8, no. 6, pp. 705-709-
dc.subject.keywordBleb formation-
dc.subject.keywordinhibitor-
dc.subject.keywordPDBu-
dc.subject.keywordK562 cells-
dc.subject.keywordchaetoglobosin A-
dc.subject.localBleb formation-
dc.subject.localinhibitor-
dc.subject.localInhibitor-
dc.subject.localPDBu-
dc.subject.localK562 cells-
dc.subject.localK562 cell-
dc.subject.localchaetoglobosin A-
dc.subject.localChaetoglobosin A-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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