Biological activities of sesquiterpene lactones isolated from several compositae plants. Part 1 Cytotoxicity against cancer cell lines = 수종의 국화과 식물에서 분리한 Sesquiterpene Lactone들의 생리활성(제1보) 암세포주에 대한 세포독성

Abstract

A diverse panel of human tumor cell lines and a mouse melanoma cell line (B16-F1) were used for the cytotoxicity test of the nine sesquiterpene lactones with α-methylene-γ-lactone group isolated from Hemisteptia lyrata, Chrysanthemum zawadskii and Chrysanthemum boreale. In the cell adhesion inhibitory activity test against B16-F1 mouse melanoma cell, hemistepcin B, cumambrin B, costunolide and tulipinolide were shown significant activities with IC50 range of 2.2, 4.1, 0.9 and 0.3 μg/ml, respectively. In the cytotoxicity test against human tumor cells, the most active compound was costunolide having IC50 values of below 0.3 μg/ml against all the tested cell lines except for UACC62. Cumambrin A, hendelin and costunolide exhibited more strong activity against HCT15 and UO-31 cell lines than a positive control, adriamycin. All tested compounds showed an IC50 values of below 5.0 μg/ml against all the tested cell lines.