Anticomplementary activity of stilbenes from medicinal plants

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Title
Anticomplementary activity of stilbenes from medicinal plants
Author(s)
Sei Ryang Oh; Shi Yong Ryu; Si Hyung Park; Keun Young Jung; Im Seon Lee; Kyung Seop Ahn; Jung Joon Lee; Hyeong Kyu Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 21, no. 6, pp. 703-706
Publication Year
1998
Abstract
The anticomplementary activity of stilbenes from medicinal plants in Korea was investigated in vitro. 3,5-Dihydroxy-4′-methoxystilbene (3) was most potent with IC50 value of 1.5×10-4 M followed by rhapontigenin (4), oxyresverastrol (2), 2,3,4′,5-tetrahydroxystilbene-2-O-β-glucoside (9), rhaponticin (8), resverastrol (1), and piceid (7). The activity was found to be increased by a methylation on a hydroxy group of C-4′ of 1, but decreased by further methylation on hydroxy groups of C-3 and C-5 and glucosylation on any hydroxy group of 1. Addition of hydroxy group on C-2′ of 1 or C-3′ of 3 was little affected on the anticomplementary activity but the activity was increased by O-glucosylation on C-2 of 1.
Keyword
2,3,4′,5-Tetrahydroxy stilbene-2-O-β-glucoside3,5-Dihydroxy-4-methoxystilbeneAnticomplementary activityOxyresveratrolPiceidResveratrolRhaponticinRhapontigeninStilbenes
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02976761
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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