Anticomplementary activity of stilbenes from medicinal plants

Abstract

The anticomplementary activity of stilbenes from medicinal plants in Korea was investigated in vitro. 3,5-Dihydroxy-4′-methoxystilbene (3) was most potent with IC50 value of 1.5×10-4 M followed by rhapontigenin (4), oxyresverastrol (2), 2,3,4′,5-tetrahydroxystilbene-2-O-β-glucoside (9), rhaponticin (8), resverastrol (1), and piceid (7). The activity was found to be increased by a methylation on a hydroxy group of C-4′ of 1, but decreased by further methylation on hydroxy groups of C-3 and C-5 and glucosylation on any hydroxy group of 1. Addition of hydroxy group on C-2′ of 1 or C-3′ of 3 was little affected on the anticomplementary activity but the activity was increased by O-glucosylation on C-2 of 1.