Anti-complement activity of tiliroside from the flower buds of magnolia fargesii

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Anti-complement activity of tiliroside from the flower buds of magnolia fargesii
Keun Young Jung; Sei Ryang Oh; Si Hyung Park; Im Seon Lee; Kyung Seop Ahn; Jung Joon Lee; Hyeong Kyu Lee
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 21, no. 10, pp. 1077-1078
Publication Year
As part of the search for anticomplementary active components from natural products, the anticomplementary properties of methanolic extracts from the flower buds of Magnolia fargesii have been investigated. Bioassay- guided chromatographic Separation of the active constituents led to the isolation of compound 1, whose structure was identified by spectroscopic methods to be kaempferol 3-O-β-D-(6-O-coumaroyl)glucopyranoside (tiliroside). Tiliroside showed very potent anti-complement activity (IC50=5.4x 10-5 M) on the classical pathway of the complement system, even higher than rosmarinic acid, which is a well-known inhibitor against the complement system. On the other hand, the hydrolysates of tiliroside, kaempferol, astragalin and p-coumaric acid showed very weak activity on this system.
tilirosideanticomplementary activityMagnolia fargesii
Pharmaceutical Soc Japan
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Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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