Roles of acetyl-CoA carboxylase β in muscle cell differentiation and in mitochondrial fatty acid oxidation

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Title
Roles of acetyl-CoA carboxylase β in muscle cell differentiation and in mitochondrial fatty acid oxidation
Author(s)
Jung Kee Lee; Ki Han Kim
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 254, pp. 657-660
Publication Year
1999
Abstract
Acetyl-CoA carboxylase β is expressed primarily in heart and skeletal muscle, where it may play a role in the control of mitochondrial fatty acid uptake and oxidation by controlling carnitine-palmitoyl-CoA transferase 1. To investigate the relationship between ACC-β expression and myoblast differentiation, we specifically blocked ACC-β production by expressing an antisense gene to the specific N-terminal region of ACC-β in H9c2 cells. The expression of the antisense ACC-β mRNA retarded cell fusion, myosin formation, and creatine kinase induction; all of these parameters are hallmarks of muscle cell differentiation. On the other hand, the rate of fatty acid oxidation was not affected by the presence or absence of ACC-β in the cells.
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1006/bbrc.1998.0113
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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