Inhibition of chitin synthase II by catechins from stem bark of Taxus cuspidata

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Title
Inhibition of chitin synthase II by catechins from stem bark of Taxus cuspidata
Author(s)
Sung Uk Kim; Eui Il Hwang; Ji Youn Nam; Kwang Hee Son; Song Hae Bok; Hong Eun Kim; Byoung-Mog Kwon
Bibliographic Citation
Planta Medica, vol. 65, pp. 97-98
Publication Year
1999
Abstract
Two flavonoids, (±)-catechin and (-)-epicatechin, were isolated from the stem bark of Taxus cuspidata by monitoring chitin synthase 11 inhibitory activity. The compounds inhibit chitin synthase II with an IC50 of 15 and 29 μg/ml, respectively and appear to be selective for chitin synthase II. They did not inhibit chitin synthase III.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2006-960453
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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