Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent

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dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorMoon Sun Hahm-
dc.contributor.authorEun Jin Park-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorIk Hwan Kim-
dc.date.accessioned2017-04-19T08:55:49Z-
dc.date.available2017-04-19T08:55:49Z-
dc.date.issued1998-
dc.identifier.issn0032-0943-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4607-
dc.description.abstractCorosolic acid isolated from the fruit of Crotaegus pinnotifido vat. psiloso was tested for anticancer activity. Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of 1(-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose- dependent pattern in an in vitro PKC assay.-
dc.publisherGeorg Thieme Verlag Kg-
dc.titleCorosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent-
dc.title.alternativeCorosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent-
dc.typeArticle-
dc.citation.titlePlanta Medica-
dc.citation.number0-
dc.citation.endPage470-
dc.citation.startPage468-
dc.citation.volume64-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorMoon Sun Hahm-
dc.contributor.affiliatedAuthorEun Jin Park-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName함문선-
dc.contributor.alternativeName박은진-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName김익환-
dc.identifier.bibliographicCitationPlanta Medica, vol. 64, pp. 468-470-
dc.identifier.doi10.1055/s-2006-957487-
dc.description.journalClassY-
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Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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