Cecropin A-melittin hybrid peptide exerts its antifungal effects by damaging on the plasma membranes of Trichosporon beigelii

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Title
Cecropin A-melittin hybrid peptide exerts its antifungal effects by damaging on the plasma membranes of Trichosporon beigelii
Author(s)
Dong Gun Lee; Song Yub Shin; Cheol Young Maeng; Kyung Soo Hahm
Bibliographic Citation
Biotechnology Letters, vol. 20, no. 3, pp. 211-214
Publication Year
1998
Abstract
To elucidate the effect of the peptide derived from cecropin A(1-8)-melittin(1-12) having potent antifungal activity without cytotoxicity against eukaryotic cell on the fungal cell membranes, Trichosporon beigelii protoplasts were prepared. The protoplasts treated with the peptide not only failed to regenerate the fungal cell walls but also disrupted the membrane, indicating that the peptide exerts its antifungal activity by acting on the plasma membranes.
ISSN
0141-5492
Publisher
Springer
DOI
http://dx.doi.org/10.1023/A:1005357314588
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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