Cecropin A-magainin 2 hybrid peptides having potent antimicrobial activity with low hemolytic effect

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dc.contributor.authorSong Yub Shin-
dc.contributor.authorJoo Hyun Kang-
dc.contributor.authorMyung Kyu Lee-
dc.contributor.authorSun Young Kim-
dc.contributor.authorYang Mee Kim-
dc.contributor.authorKyung Soo Hahm-
dc.date.accessioned2017-04-19T08:55:50Z-
dc.date.available2017-04-19T08:55:50Z-
dc.date.issued1998-
dc.identifier.issn1039-9712-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4616-
dc.description.abstractIn order to obtain peptides having improved antimicrobial activity with low hemolytic effect, a hybrid peptide (CA-MA) composed from cecropin A(1-8) and magainin 2(1-12), and its analogues with amino acid substitutions were designed and synthesized. The antimicrobial activities against bacterial cells and hemolytic activities against human red blood cells were analyzed for each peptide. Secondary structures of the peptides in aqueous solution, 50% trifluoroethanol, and sodium dodecylsulfate micelles were estimated using circular dichroism spectroscopy. The increase in hydrophobicity or α-helicity of the peptides correlated with an increase in hemolytic activity rather than antimicrobial activity. The substitution of Leu for Ser at position 16 in CA-MA resulted in a remarkable increase in antimicrobial activity without a significant change in hemolytic activity. Furthermore, the increase in antimicrobial activity of the peptides was not always accompanied by the increase in hemolytic activity.-
dc.publisherWiley-
dc.titleCecropin A-magainin 2 hybrid peptides having potent antimicrobial activity with low hemolytic effect-
dc.title.alternativeCecropin A-magainin 2 hybrid peptides having potent antimicrobial activity with low hemolytic effect-
dc.typeArticle-
dc.citation.titleBiochemistry and Molecular Biology International-
dc.citation.number6-
dc.citation.endPage1126-
dc.citation.startPage1119-
dc.citation.volume44-
dc.contributor.affiliatedAuthorSong Yub Shin-
dc.contributor.affiliatedAuthorJoo Hyun Kang-
dc.contributor.affiliatedAuthorMyung Kyu Lee-
dc.contributor.affiliatedAuthorSun Young Kim-
dc.contributor.affiliatedAuthorKyung Soo Hahm-
dc.contributor.alternativeName신송엽-
dc.contributor.alternativeName강주현-
dc.contributor.alternativeName이명규-
dc.contributor.alternativeName김선영-
dc.contributor.alternativeName김양미-
dc.contributor.alternativeName함경수-
dc.identifier.bibliographicCitationBiochemistry and Molecular Biology International, vol. 44, no. 6, pp. 1119-1126-
dc.identifier.doi10.1080/15216549800202192-
dc.subject.keywordantimicrobial activity-
dc.subject.keywordCA-MA hybrid peptide-
dc.subject.keywordhelicity-
dc.subject.keywordhemolytic activity-
dc.subject.keywordhydrophobicity-
dc.subject.localAntimicrobial activity-
dc.subject.localantimicrobial activity-
dc.subject.localantimicrobial activities-
dc.subject.localCA-MA hybrid peptide-
dc.subject.localhelicity-
dc.subject.localHemolytic activity-
dc.subject.localhemolytic activity-
dc.subject.localhydrophobicity-
dc.subject.localHydrophobicity-
dc.description.journalClassY-
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