Acyl-CoA:cholesterol acyltransferase inhibitory activity of lignans isolated from Schizandra, Machilus and Magnolia species

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Title
Acyl-CoA:cholesterol acyltransferase inhibitory activity of lignans isolated from Schizandra, Machilus and Magnolia species
Author(s)
Byoung-Mog Kwon; Hyun Ju Jung; Jung Hee Lim; Youn Soo Kim; Mi Kyung Kim; Young Kook Kim; Song Hae Bok; Ki Hwan Bae; Ihn Rhan Lee
Bibliographic Citation
Planta Medica, vol. 65, pp. 74-76
Publication Year
1999
Abstract
Fifteen lignans were isolated from the fruits of Schizandra chinensis, the leaves of Machilus thunbergii, and the flower buds of Magnolia denudata. They were identified as gomisins, schizandrin, wuweizisu, schizantherin, licarins, and machilin, which inhibited rat liver ACAT with IC50 values of 25-200 μM. Gomisin N is the most potent inhibitor with IC50 value of 25 μM in these lignans.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2006-960443
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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