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- Title
- A nucleoside with lipid peroxidation inhibitory activity from Agrocybe cylindracea = 버들송이로부터 분리한 Nucleoside계 화합물의 지질과산화 저해활성
- Author(s)
- In Kyoung Lee; Bong Sik Yun; Ick Dong Yoo
- Bibliographic Citation
- Korean Journal of (Applied) Microbiology & Biotechnology, vol. 26, no. 6, pp. 558-561
- Publication Year
- 1998
- Abstract
- In the screening for lipid peroxidation inhibitors from edible mushroom, Agrocybe cylindracea, a bioactive compound AG 8 was isolated. The AG 8 was purified from methanol extract of its fruit body by Diaion HP-20 column chromatography, ethyl acetate extraction, and silica gel column chromatography, consecutively. Based on various NMR studies including 1H irradiation and HMBC experiments, the AG 8 was identified as MTA, 5'-deoxy- 5'-methylthioadenosine. This compound inhibited lipid peroxidation with an IC50 value of 3.2 μg/ml. The MTA was isolated for the first time from basidiomycetes.
- Keyword
- Agrocybe cylindracea5'-deoxy-5'-methylthioadenosinemushroomNMRlipid peroxidation inhibitor
- ISSN
- 0257-2389
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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