A nucleoside with lipid peroxidation inhibitory activity from Agrocybe cylindracea = 버들송이로부터 분리한 Nucleoside계 화합물의 지질과산화 저해활성

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Title
A nucleoside with lipid peroxidation inhibitory activity from Agrocybe cylindracea = 버들송이로부터 분리한 Nucleoside계 화합물의 지질과산화 저해활성
Author(s)
In Kyoung Lee; Bong Sik Yun; Ick Dong Yoo
Bibliographic Citation
Korean Journal of (Applied) Microbiology & Biotechnology, vol. 26, no. 6, pp. 558-561
Publication Year
1998
Abstract
In the screening for lipid peroxidation inhibitors from edible mushroom, Agrocybe cylindracea, a bioactive compound AG 8 was isolated. The AG 8 was purified from methanol extract of its fruit body by Diaion HP-20 column chromatography, ethyl acetate extraction, and silica gel column chromatography, consecutively. Based on various NMR studies including 1H irradiation and HMBC experiments, the AG 8 was identified as MTA, 5'-deoxy- 5'-methylthioadenosine. This compound inhibited lipid peroxidation with an IC50 value of 3.2 μg/ml. The MTA was isolated for the first time from basidiomycetes.
Keyword
Agrocybe cylindracea5'-deoxy-5'-methylthioadenosinemushroomNMRlipid peroxidation inhibitor
ISSN
0257-2389
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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