A mannofucogalactan, fomitellan A, with mitogneic effect from fruit bodies of Fomitella fraxinea (Imaz.)

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Title
A mannofucogalactan, fomitellan A, with mitogneic effect from fruit bodies of Fomitella fraxinea (Imaz.)
Author(s)
Soo Muk Cho; Hiroyuki Koshino; Seung Hun Yu; Ick Dong Yoo
Bibliographic Citation
Carbohydrate Polymers, vol. 37, pp. 13-18
Publication Year
1998
Abstract
A heterogalactan, fomitellan A, was isolated from a 0.9% sodium chloride extract of the fruit bodies of Fomitella fraxinea by a combination of fractionation procedures, including precipitation with ethanol and chromatography on columns of DEAE-cellulose and Toyopearl HW 65F. On employing gel permeation-high performance liquid chromatograpy, fomitellan A exhibited a single peak with a molecular weight of 15 kDa. The results of methylation, and 1H and 13C NMR spectroscopic analyses indicated that the heterogalactan fomitellan A was a repeating unit (pentasaccharide) composed of a backbone with (1 → 6)-linked D-galactopyranosyl residues. Its C-2 atom position was substituted with disaccharide units of 3-O-D-mannopyranosyl-L-fucopyranosyl residues. The fucomannaogalactan (fomitellan A) from Fomitella fraxinea showed pronounced immunostimulating activity in an in vitro lymphocytes proliferation assay.
Keyword
MannofucogalactanFomitellan AMitogenic effectFomitella fraxinea
ISSN
0144-8617
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0144-8617(98)00041-1
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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