DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ji Won Yoon | - |
dc.contributor.author | Chang Soon Yoon | - |
dc.contributor.author | Hye Won Lim | - |
dc.contributor.author | Q Q Huang | - |
dc.contributor.author | Yup Kang | - |
dc.contributor.author | Kwang Ho Pyun | - |
dc.contributor.author | K Hirasawa | - |
dc.contributor.author | R S Sherwin | - |
dc.contributor.author | Hee Sook Jun | - |
dc.date.accessioned | 2017-04-19T08:55:55Z | - |
dc.date.available | 2017-04-19T08:55:55Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/4660 | - |
dc.description.abstract | Glutamic and decarboxylase (GAD) is a pancreatic β cell autoantigen in humans and nonobese diabetic (NOD) mice. β Cell-specific suppression of GAD expression in two lines of antisense GAD transgenic NOD mice prevented autoimmune diabetes, whereas persistent GAD expression in the β cells in the other four lines of antisense GAD transgenic NOD mice resulted in diabetes, similar to that seen in transgene-negative NOD mice. Complete suppression of β cell GAD expression blocked the generation of diabetogenic T cells and protected islet grafts from autoimmune injury. Thus, β cell-specific GAD expression is required for the development of autoimmune diabetes in NOD mice, and modulation of GAD might, therefore, have therapeutic value in type 1 diabetes. | - |
dc.publisher | Amer Assoc Advancement Science | - |
dc.title | Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β-cells | - |
dc.title.alternative | Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β-cells | - |
dc.type | Article | - |
dc.citation.title | Science | - |
dc.citation.number | 5417 | - |
dc.citation.endPage | 1187 | - |
dc.citation.startPage | 1183 | - |
dc.citation.volume | 284 | - |
dc.contributor.affiliatedAuthor | Kwang Ho Pyun | - |
dc.contributor.alternativeName | 윤지원 | - |
dc.contributor.alternativeName | 윤창순 | - |
dc.contributor.alternativeName | 임혜원 | - |
dc.contributor.alternativeName | Huang | - |
dc.contributor.alternativeName | 강엽 | - |
dc.contributor.alternativeName | 변광호 | - |
dc.contributor.alternativeName | Hirasawa | - |
dc.contributor.alternativeName | Sherwin | - |
dc.contributor.alternativeName | 전희숙 | - |
dc.identifier.bibliographicCitation | Science, vol. 284, no. 5417, pp. 1183-1187 | - |
dc.identifier.doi | 10.1126/science.284.5417.1183 | - |
dc.description.journalClass | Y | - |
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