Chitin synthase II inhibitory activity of urosolic acid, isolated from Crataegus pinnatifida

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dc.contributor.authorTae Sook Jeong-
dc.contributor.authorEui Il Hwang-
dc.contributor.authorHyang Bok Lee-
dc.contributor.authorEun Sook Lee-
dc.contributor.authorYoung Kook Kim-
dc.contributor.authorByung Sun Min-
dc.contributor.authorKi Hwan Bae-
dc.contributor.authorSong Hae Bok-
dc.contributor.authorSung Uk Kim-
dc.date.accessioned2017-04-19T08:55:57Z-
dc.date.available2017-04-19T08:55:57Z-
dc.date.issued1999-
dc.identifier.issn0032-0943-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4672-
dc.description.abstractTwo triterpenoid compounds, ursolic acid and uvaol, were isolated from Crataegus pinnatifida Bunge leaves. Ursolic acid inhibits chitin synthase II from S. cerevisiae with an IC50 value of 0.84 μ/ml and the inhibition appears to be selective for chitin synthase II, whereas uvaol has no inhibitory activity up to 280 μg/ml. Oleanolic acid, α-hederin hydrate, and betulic acid inhibited the chitin synthase II activity under the same conditions with an IC50 of 5.6, 64.3, and 98.7 μg/ml, respectively.-
dc.publisherGeorg Thieme Verlag Kg-
dc.titleChitin synthase II inhibitory activity of urosolic acid, isolated from Crataegus pinnatifida-
dc.title.alternativeChitin synthase II inhibitory activity of urosolic acid, isolated from Crataegus pinnatifida-
dc.typeArticle-
dc.citation.titlePlanta Medica-
dc.citation.number3-
dc.citation.endPage263-
dc.citation.startPage261-
dc.citation.volume65-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.affiliatedAuthorEui Il Hwang-
dc.contributor.affiliatedAuthorHyang Bok Lee-
dc.contributor.affiliatedAuthorEun Sook Lee-
dc.contributor.affiliatedAuthorYoung Kook Kim-
dc.contributor.affiliatedAuthorByung Sun Min-
dc.contributor.affiliatedAuthorSong Hae Bok-
dc.contributor.affiliatedAuthorSung Uk Kim-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName황의일-
dc.contributor.alternativeName이향복-
dc.contributor.alternativeName이은숙-
dc.contributor.alternativeName김영국-
dc.contributor.alternativeName민병선-
dc.contributor.alternativeName배기환-
dc.contributor.alternativeName복성해-
dc.contributor.alternativeName김성욱-
dc.identifier.bibliographicCitationPlanta Medica, vol. 65, no. 3, pp. 261-263-
dc.identifier.doi10.1055/s-2006-960474-
dc.description.journalClassY-
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Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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