Inhibition of human tumor growth by 2'-hydroxy-and 2'-benzoyloxycinnamaldehydes

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Title
Inhibition of human tumor growth by 2'-hydroxy-and 2'-benzoyloxycinnamaldehydes
Author(s)
C W Lee; Dong Ho Hong; Sang Bae Han; S H Park; H K Kim; Byoung-Mog Kwon; Hwan Mook Kim
Bibliographic Citation
Planta Medica, vol. 65, no. 3, pp. 263-266
Publication Year
1999
Abstract
2'-Hydroxycinnamaldehyde (HCA) was isolated from Cinnamomum cassia Blume (Lauraceae) and 2'-benzoyloxycinnamaldehyde (BCA) was prepared by the reaction of HCA and benzoyl chloride. HCA and BCA strongly inhibited in vitro growth of 29 kinds of human cancer cells and in vivo growth of SW-620 human tumor xenograft without the loss of body weight in nude mice. HCA prevented adherence of SW-620 cells to the culture surface but did not inhibit oncogenic K-Ras processing, implying its antitumor mechanisms at the cellular level.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2006-960772
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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