The inhibitory effect of polysaccharides isolated from phellinus linteus on tumor growth and metastasis

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Title
The inhibitory effect of polysaccharides isolated from phellinus linteus on tumor growth and metastasis
Author(s)
Sang Bae Han; Chang Woo Lee; Young Jin Jeon; Nam Doo Hong; Ick Dong Yoo; Kyu-Hwan Yang; Hwan Mook Kim
Bibliographic Citation
Immunopharmacology, vol. 41, no. 2, pp. 157-164
Publication Year
1999
Abstract
It was previously reported that polysaccharides (PL) isolated from Phellinus linteus strongly stimulated cell-mediated and humoral immunity. This study was undertaken to investigate the immunochemotherapeutic activity of PL against tumor growth and metastasis. PL alone significantly prolonged the survival rate of B16F10-implanted mice, inhibited tumor growth in NCI-H23-implanted nude mice, and reduced the frequency of pulmonary metastasis of B16F10 melanoma. Adriamycin significantly inhibited tumor growth, but only slightly inhibited metastasis. The combination therapy with PL and adriamycin was more effective in inhibiting tumor growth, but not metastasis. PL did not induce direct toxicity in cancer cells, which is characteristic of immunotherapeutics. In conclusion, PL might be of use in immunochemotherapy of cancer because of its effective activities on tumor growth and metastasis through the immunopotentiation of the patients without toxicity.
Keyword
Phellinus linteusAdriamycinImmunochemotherapyTumor growthMetastasis
ISSN
0162-3109
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0162-3109(98)00063-0
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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