Acyl-CoA: cholesterol acyltransferase inhibitory activity of ginseng sapogenins, produced from the ginseng saponins

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Title
Acyl-CoA: cholesterol acyltransferase inhibitory activity of ginseng sapogenins, produced from the ginseng saponins
Author(s)
Byoung-Mog Kwon; Mi Kyung Kim; Nam In Baek; Dong Sung Kim; Jong Dae Park; Young Kook Kim; Hyung Kyu Lee; Shin Il Kim
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 9, no. 10, pp. 1375-1378
Publication Year
1999
Abstract
Ginseng sapogenins were produced from ginseng saponins, isolated from Korean ginseng roots. Ginseng saponins very mildly inhibited acyl- CoA:cholesterol acyltransferase (ACAT) in vitro, however, the sapogenins showed strong inhibitory activity on microsomal ACAT. Therefore, the sapogenins will be one of key ingredients of ginseng affected a lowering of the serum total cholesterol level.
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0960-894X(99)00208-5
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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