Plasma and hepatic cholesterol and hepatic activites of 3-hydroxy-3-methyl-glutaryl-CoA reductase and Acyl Coa: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids

Cited 328 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorSong Hae Bok-
dc.contributor.authorSung Heui Lee-
dc.contributor.authorYong Bok park-
dc.contributor.authorKi Hwan Bae-
dc.contributor.authorKwang Hee Son-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorMyung Sook Choi-
dc.date.accessioned2017-04-19T08:56:01Z-
dc.date.available2017-04-19T08:56:01Z-
dc.date.issued1999-
dc.identifier.issn0022-3166-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4696-
dc.description.abstractThe cholesterol-lowering effects of tangerine peel extract and a mixture of two citrus flavonoids were tested. Male rats were fed a 1 g/100 g high- cholesterol diet for 42 d with supplements of either tangerine-peel extract or a mixture of naringin and hesperidin (0.5 g/100 g) to study the effects of plasma and hepatic lipids, hepatic enzyme activities, and the excretion of fecal neutral sterols. Both the tangerine-peel extract and mixture of two flavonoids significantly lowered the levels (mean ± SE) of plasma (2.44 ± 0.59 and 2.42 ± 0.31 mmol/L, vs. 3.80 ± 0.28 mmol/L, P < 0.05), hepatic cholesterol (0.143 ± 0.017 and 0.131 ± 0.010 mmol/g vs. 0.181 ± 0.003 mmol/g, P < 0.05), and hepatic triglycerides (0.069 ± 0.007 and 0.075 ± 0.006 mmol/g vs. 0.095 ± 0.002 mmol/g, P < 0.05) compared to those of the control. The 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase (1565.0 ± 106.0 pmol · min-1 · mg protein-1 and 1783.0 ± 282 pmol · min-1 mg protein-1 vs. 2487.0 ± 210.0 pmol · min-1 · mg protein-1, P < 0.05) and acyl CoA: cholesterol O-acyltransferase (ACAT) activities (548.0 ± 65.0 and 615.0 ± 80.0 pmol · min-1 · mg protein-1 vs. 806.0 ± 105.0 pmol min-1 · mg protein-1, P < 0.05) were significantly lower in the experimental groups than in the control. These supplements also substantially reduced the excretion of fecal neutral sterols compared to the control (211.1 ± 26.7 and 208.2 ± 31.6 mg/d vs. 521.9 ± 53.9 mg/d). The inhibition of HMG-CoA reductase and ACAT activities resulting from the supplementation of either tangerine-peel extract or a combination of its bioflavonoids could account for the decrease in fecal neutral sterol that appears to compensate for the decreased cholesterol biosynthesis in the liver.-
dc.publisherOxford Univ Press-
dc.titlePlasma and hepatic cholesterol and hepatic activites of 3-hydroxy-3-methyl-glutaryl-CoA reductase and Acyl Coa: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids-
dc.title.alternativePlasma and hepatic cholesterol and hepatic activites of 3-hydroxy-3-methyl-glutaryl-CoA reductase and Acyl Coa: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids-
dc.typeArticle-
dc.citation.titleJournal of Nutrition-
dc.citation.number6-
dc.citation.endPage1185-
dc.citation.startPage1182-
dc.citation.volume129-
dc.contributor.affiliatedAuthorSong Hae Bok-
dc.contributor.affiliatedAuthorKwang Hee Son-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName복성해-
dc.contributor.alternativeName이성희-
dc.contributor.alternativeName박용복-
dc.contributor.alternativeName배기환-
dc.contributor.alternativeName손광희-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName최명숙-
dc.identifier.bibliographicCitationJournal of Nutrition, vol. 129, no. 6, pp. 1182-1185-
dc.identifier.doi10.1093/jn/129.6.1182-
dc.subject.keywordhesperidin-
dc.subject.keywordnaringin-
dc.subject.keywordHMG-CoA reductase-
dc.subject.keywordACAT-
dc.subject.keywordtangerine peel extract-
dc.subject.keywordrats-
dc.subject.localHesperidin-
dc.subject.localhesperidin-
dc.subject.localNaringin-
dc.subject.localnaringin-
dc.subject.localHMG-CoA reductase-
dc.subject.localACAT (acyl-CoA: cholesterol acyltransferase)-
dc.subject.localAcyl-CoA:cholesterol acyltransferase (ACAT)-
dc.subject.localcholesterol acytransferase (ACAT)-
dc.subject.localCholestrol Acyl Transferase (ACAT)-
dc.subject.localAcyl CoA: cholesterol acyltransferase (ACAT)-
dc.subject.localACAT (Acyl-CoA:cholesterol acyltransferase)-
dc.subject.localAcyl-CoA:cholesterol acyltransferase-
dc.subject.localACAT-
dc.subject.localAcyl-CoA: cholesterol acyltransferase-
dc.subject.localacyl-CoA:cholesterol acyltransferase (ACAT)-
dc.subject.localAcyl-CoA: cholesterol acyltransferase (ACAT)-
dc.subject.localAcyl-coenzyme A: cholesterol acyltransferase (ACAT)-
dc.subject.localCholesterol acytransferase (ACAT)-
dc.subject.localcholestrol acyl transferase (ACAT)-
dc.subject.localtangerine peel extract-
dc.subject.localRat-
dc.subject.localrat-
dc.subject.localRats-
dc.subject.localrats-
dc.subject.localRat.-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.