DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song Hae Bok | - |
dc.contributor.author | Sung Heui Lee | - |
dc.contributor.author | Yong Bok park | - |
dc.contributor.author | Ki Hwan Bae | - |
dc.contributor.author | Kwang Hee Son | - |
dc.contributor.author | Tae Sook Jeong | - |
dc.contributor.author | Myung Sook Choi | - |
dc.date.accessioned | 2017-04-19T08:56:01Z | - |
dc.date.available | 2017-04-19T08:56:01Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0022-3166 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/4696 | - |
dc.description.abstract | The cholesterol-lowering effects of tangerine peel extract and a mixture of two citrus flavonoids were tested. Male rats were fed a 1 g/100 g high- cholesterol diet for 42 d with supplements of either tangerine-peel extract or a mixture of naringin and hesperidin (0.5 g/100 g) to study the effects of plasma and hepatic lipids, hepatic enzyme activities, and the excretion of fecal neutral sterols. Both the tangerine-peel extract and mixture of two flavonoids significantly lowered the levels (mean ± SE) of plasma (2.44 ± 0.59 and 2.42 ± 0.31 mmol/L, vs. 3.80 ± 0.28 mmol/L, P < 0.05), hepatic cholesterol (0.143 ± 0.017 and 0.131 ± 0.010 mmol/g vs. 0.181 ± 0.003 mmol/g, P < 0.05), and hepatic triglycerides (0.069 ± 0.007 and 0.075 ± 0.006 mmol/g vs. 0.095 ± 0.002 mmol/g, P < 0.05) compared to those of the control. The 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase (1565.0 ± 106.0 pmol · min-1 · mg protein-1 and 1783.0 ± 282 pmol · min-1 mg protein-1 vs. 2487.0 ± 210.0 pmol · min-1 · mg protein-1, P < 0.05) and acyl CoA: cholesterol O-acyltransferase (ACAT) activities (548.0 ± 65.0 and 615.0 ± 80.0 pmol · min-1 · mg protein-1 vs. 806.0 ± 105.0 pmol min-1 · mg protein-1, P < 0.05) were significantly lower in the experimental groups than in the control. These supplements also substantially reduced the excretion of fecal neutral sterols compared to the control (211.1 ± 26.7 and 208.2 ± 31.6 mg/d vs. 521.9 ± 53.9 mg/d). The inhibition of HMG-CoA reductase and ACAT activities resulting from the supplementation of either tangerine-peel extract or a combination of its bioflavonoids could account for the decrease in fecal neutral sterol that appears to compensate for the decreased cholesterol biosynthesis in the liver. | - |
dc.publisher | Oxford Univ Press | - |
dc.title | Plasma and hepatic cholesterol and hepatic activites of 3-hydroxy-3-methyl-glutaryl-CoA reductase and Acyl Coa: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids | - |
dc.title.alternative | Plasma and hepatic cholesterol and hepatic activites of 3-hydroxy-3-methyl-glutaryl-CoA reductase and Acyl Coa: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids | - |
dc.type | Article | - |
dc.citation.title | Journal of Nutrition | - |
dc.citation.number | 6 | - |
dc.citation.endPage | 1185 | - |
dc.citation.startPage | 1182 | - |
dc.citation.volume | 129 | - |
dc.contributor.affiliatedAuthor | Song Hae Bok | - |
dc.contributor.affiliatedAuthor | Kwang Hee Son | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.alternativeName | 복성해 | - |
dc.contributor.alternativeName | 이성희 | - |
dc.contributor.alternativeName | 박용복 | - |
dc.contributor.alternativeName | 배기환 | - |
dc.contributor.alternativeName | 손광희 | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.contributor.alternativeName | 최명숙 | - |
dc.identifier.bibliographicCitation | Journal of Nutrition, vol. 129, no. 6, pp. 1182-1185 | - |
dc.identifier.doi | 10.1093/jn/129.6.1182 | - |
dc.subject.keyword | hesperidin | - |
dc.subject.keyword | naringin | - |
dc.subject.keyword | HMG-CoA reductase | - |
dc.subject.keyword | ACAT | - |
dc.subject.keyword | tangerine peel extract | - |
dc.subject.keyword | rats | - |
dc.subject.local | Hesperidin | - |
dc.subject.local | hesperidin | - |
dc.subject.local | Naringin | - |
dc.subject.local | naringin | - |
dc.subject.local | HMG-CoA reductase | - |
dc.subject.local | ACAT (acyl-CoA: cholesterol acyltransferase) | - |
dc.subject.local | Acyl-CoA:cholesterol acyltransferase (ACAT) | - |
dc.subject.local | cholesterol acytransferase (ACAT) | - |
dc.subject.local | Cholestrol Acyl Transferase (ACAT) | - |
dc.subject.local | Acyl CoA: cholesterol acyltransferase (ACAT) | - |
dc.subject.local | ACAT (Acyl-CoA:cholesterol acyltransferase) | - |
dc.subject.local | Acyl-CoA:cholesterol acyltransferase | - |
dc.subject.local | ACAT | - |
dc.subject.local | Acyl-CoA: cholesterol acyltransferase | - |
dc.subject.local | acyl-CoA:cholesterol acyltransferase (ACAT) | - |
dc.subject.local | Acyl-CoA: cholesterol acyltransferase (ACAT) | - |
dc.subject.local | Acyl-coenzyme A: cholesterol acyltransferase (ACAT) | - |
dc.subject.local | Cholesterol acytransferase (ACAT) | - |
dc.subject.local | cholestrol acyl transferase (ACAT) | - |
dc.subject.local | tangerine peel extract | - |
dc.subject.local | Rat | - |
dc.subject.local | rat | - |
dc.subject.local | Rats | - |
dc.subject.local | rats | - |
dc.subject.local | Rat. | - |
dc.description.journalClass | Y | - |
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