Uncarinic acids: phospholipase Cγ1 inhibitors from hooks of Uncaria rhynchophylla

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Title
Uncarinic acids: phospholipase Cγ1 inhibitors from hooks of Uncaria rhynchophylla
Author(s)
Ji Suk Lee; Mi Young Yang; Ho Sup Yeo; Jin Woong Kim; Hyun Sun Lee; Jong Seog Ahn
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 9, pp. 1429-1432
Publication Year
1999
Abstract
Bioactivity-guided fractionation of the CHCl3 extract from hooks of Uncaria rhynchophylla led to the isolation of two triterpene esters, namely uncarinic acids A (1) and B (2). Their structures were established by spectroscopic and chemical methods. These compounds inhibited phospholipase Cγ1 with IC50 values of 3 5.66 and 44.55 μM, respectively.
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0960-894X(99)00211-5
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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