천연물 Polygodial과 Imidazole계 화합물의 병용에 의한 항진균 활성의 증진

Cited 0 time in scopus
Metadata Downloads
Title
천연물 Polygodial과 Imidazole계 화합물의 병용에 의한 항진균 활성의 증진
Author(s)
Sang Hwa Lee; Jae Ran Lee; Chang Jin Kim
Bibliographic Citation
Yakhak Hoeji, vol. 43, no. 2, pp. 221-227
Publication Year
1999
Abstract
The fungistatic and the fungicidal activities of amphotericin B, fluconazole, miconazole, econazole, and 5-fluorocytosine against Saccharomyces cerevisiae were estimated in the presence of 1/2 minimum inhibitory concentration (MIC) and 1/2 minimum fungicidal concentration (MFC) of polygodial, respectively. Among them, the antifungal activities of miconazole and econazole were greatly (32-128 fold) enhanced by polygodial. The potentiated activity of the imidazoles by polygodial was still shown against several yeast-like fungi including Candida albicans, Candida utilis, and Cryptococcus neoformans, except for Candida krusei. The combination of polygodial with imidazole drugs against Saccharomyces cerevisiae was further examined using the macrobroth dilution checkerboard method. The fractional inhibitory concentration (FIC) and the fractional fungicidal concentration (FFC) index between polygodial and miconazole were 0.16 and 0.19, while the combination of polygodial with econazole exhibited the FIC index of 0.19 and the FFC of 0.25, respectively. These results suggest that polygodial and the imidazoles on the fungistatic and fungicidal action are highly synergistic.
Keyword
polygodialeconazolemiconazolesynergistic
ISSN
0513-4242
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.