Sophoricoside analogs as the IL-5 inhibitors from sophora japonica

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Title
Sophoricoside analogs as the IL-5 inhibitors from sophora japonica
Author(s)
Bok Gi Min; Sei Ryang Oh; Hyeong Kyu Lee; Kiyoshi Takatsu; Il Moo Chang; Kyung Rak Min; Young Soo Kim
Bibliographic Citation
Planta Medica, vol. 65, pp. 408-412
Publication Year
1999
Abstract
Fruits of Sophora japonica L. (Leguminosae) exhibited an inhibitory effect in the IL-5 bioassay of mIL-5-dependent Y16 proliferation. The isoflavonoids of sophoricoside, genistein, orobol, and genistin were isolated as the IL-5 inhibitors from fresh fruits of the plant by activity-guided fractionation. Among the IL-5 inhibitors, sophoricoside exhibited the highest inhibitory effect with 89% inhibition at 12.5 μM, 82% at 6.3 μM, 72% at 3.1 μM, 59% at 1.6 μM, and 24% at 0.8 μM where the 50% inhibition (IC50) was shown at the concentration of 1.5 μM. Oxyphenylbutazone as the positive control exhibited the IC50 value at the concentration of 31.7 μM. In the order of IC50 values the inhibitory potency in the IL-5 bioassay was sophoricoside > orobol (9.8 μM) ? genistin (10.6 μM) > genistein (51.9 μM). The position of O-glycosylation and number of hydroxy groups in the isoflavonoids seem to play an important role in the inhibitory effect in the IL-5 bioassay.
Keyword
orobolgenistinsophoricosideSophora japonicaLeguminosaeIL-5 inhibitor
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-1999-14016
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
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