In vitro anticomplementary activity of hederagenin saponins isolated from roots of dipsacus asper

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dc.contributor.authorSei Ryang Oh-
dc.contributor.authorKeun Young Jung-
dc.contributor.authorKun Ho Son-
dc.contributor.authorSi Hyung Park-
dc.contributor.authorIm Seon Lee-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorHyeong Kyu Lee-
dc.date.accessioned2017-04-19T08:56:05Z-
dc.date.available2017-04-19T08:56:05Z-
dc.date.issued1999-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4723-
dc.description.abstractAnticomplementary activity of hederagenin and related saponins isolated from Dipsacus asper was investigated in vitro. HN saponin F (3) was most potent with IC50 value of 3.7×10-5 M followed by 3-O-β-D-glucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)- β-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyrano side (8), 3-O-β-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (5), dipsacus saponin A (4), and hederagenin (1) on the classical pathway (CP) of complement system, while the saponins 3-5 did not show the inhibition of hemolysis and rather increase the hemolysis on the alternative pathway (AP). However, all of C-3 monodesmosides [prosapogenin CP (2), dipsacus saponin B (6), and dipsacus saponin C (7)] evoked hemolysis directly on the erythrocytes.-
dc.publisherPharmaceutical Soc Korea-
dc.titleIn vitro anticomplementary activity of hederagenin saponins isolated from roots of dipsacus asper-
dc.title.alternativeIn vitro anticomplementary activity of hederagenin saponins isolated from roots of dipsacus asper-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number3-
dc.citation.endPage319-
dc.citation.startPage317-
dc.citation.volume22-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorIm Seon Lee-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName정근영-
dc.contributor.alternativeName손건호-
dc.contributor.alternativeName박시형-
dc.contributor.alternativeName이임선-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName이형규-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 22, no. 3, pp. 317-319-
dc.identifier.doi10.1007/BF02976371-
dc.subject.keywordAnticomplementary activity-
dc.subject.keywordHederagenin-
dc.subject.keywordHederagenin saponins-
dc.subject.keywordDipsacus asper-
dc.subject.localanticomplementary actvity-
dc.subject.localAnticomplementary activity-
dc.subject.localAnti-complementary activity-
dc.subject.localanti-complementary activity-
dc.subject.localanticomplementary activity-
dc.subject.localHederagenin-
dc.subject.localHederagenin saponins-
dc.subject.localDipsacus asper-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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