Structure and antibiotic activity of fragment peptides of antifungal protein isolated from Aspergillus giganteus

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dc.contributor.authorSong Yub Shin-
dc.contributor.authorJoo Hyun Kang-
dc.contributor.authorDong Gun Lee-
dc.contributor.authorZhe Zhu Jin-
dc.contributor.authorSo Youn Jang-
dc.contributor.authorKil Lyong Kim-
dc.contributor.authorKyung Soo Hahm-
dc.date.accessioned2017-04-19T08:56:09Z-
dc.date.available2017-04-19T08:56:09Z-
dc.date.issued1999-
dc.identifier.issn10177825-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4754-
dc.description.abstractIn order to determine the functional region of the antifungal protein (AFP) isolated from Aspergillus giganteus responsible for growth inhibitory activity and the promotion of phospholipid vesicle aggregation, overlapping peptides covering the complete sequence of AFP were synthesized. The antibiotic activity against bacterial, fungal, and tumor cells, and the vesicle-aggregation activity of the synthetic peptides were investigated. The AFP functional sequence responsible for antibiotic and vesicle-aggregation activity was determined to be located within the region between AFP residues 19 to 32. AFP (19-32) exhibited an α-helical conformation in a cell membrane-like environment. AFP (19-32) displayed potent antibiotic activity against bacterial, fungal, and tumor cells without peptide toxicity as indicated by hemolysis. Accordingly, AFP (19-32) could be used as a good model for the design of effective antibiotic agents with powerful antibiotic activity yet without any cytotoxic effects against the host organism.-
dc.publisherSouth Korea-
dc.titleStructure and antibiotic activity of fragment peptides of antifungal protein isolated from Aspergillus giganteus-
dc.title.alternativeStructure and antibiotic activity of fragment peptides of antifungal protein isolated from Aspergillus giganteus-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number3-
dc.citation.endPage281-
dc.citation.startPage276-
dc.citation.volume9-
dc.contributor.alternativeName신송엽-
dc.contributor.alternativeName강주현-
dc.contributor.alternativeName이동건-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName장소윤-
dc.contributor.alternativeName김길룡-
dc.contributor.alternativeName함경수-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 9, no. 3, pp. 276-281-
dc.subject.keywordAspergillus giganteus-
dc.subject.keywordanfifungal protein-
dc.subject.keywordfragment peptides-
dc.subject.keywordfunctional sequence-
dc.subject.localAspergillus giganteus-
dc.subject.localanfifungal protein-
dc.subject.localfragment peptides-
dc.subject.localfunctional sequence-
dc.description.journalClassY-
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