DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dong Gun Lee | - |
dc.contributor.author | Zhe Zhu Jin | - |
dc.contributor.author | Cheol Young Maeng | - |
dc.contributor.author | Song Yub Shin | - |
dc.contributor.author | Moo Yeol Seo | - |
dc.contributor.author | Kil Lyong Kim | - |
dc.contributor.author | Kyung Soo Hahm | - |
dc.date.accessioned | 2017-04-19T08:56:09Z | - |
dc.date.available | 2017-04-19T08:56:09Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/4755 | - |
dc.description.abstract | The antifungal mechanism of the antifungal peptide against Aspergillus fumigatus, K18,19CA-(1-8)-ME(1-12), derived from cecropin A(1-8)- melittin(1-12) was investigated by confocal laser scanning microscopy, cell wall regeneration, ATPase activity inhibition, and released potassium ion. By confocal laser scanning microscopy, K18,19-CA(1-8)-ME(1-12) was detected on the surface of A. fumigatus, while cecropin A used as a negative control peptide was not detected. The protoplast of A. fumigatus treated with K18,19-CA(1-8)-ME(1-12) failed to regenerate the fungal cell walls. Compared with cecropin A, the amount of potassium ion released by K18,19-CA(1-8)-ME(1-12) was increased. Furthermore, K18,19-CA(1-8)-ME(1- 12) inhibited the ATPase activity on the plasma membrane. These results suggested that K18,19-CA(1-8)-ME (1-12) acts on the plasma membrane of A. fumigatus and its antifungal action is due to the ion channel or pore formation on the plasma membrane. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Antifungal mechanism of antifungal peptide derived from cecropin A(1-8)-melittin(1-12) hybrid against Aspergillus fumigatus | - |
dc.title.alternative | Antifungal mechanism of antifungal peptide derived from cecropin A(1-8)-melittin(1-12) hybrid against Aspergillus fumigatus | - |
dc.type | Article | - |
dc.citation.title | Journal of Microbiology and Biotechnology | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 172 | - |
dc.citation.startPage | 168 | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Dong Gun Lee | - |
dc.contributor.affiliatedAuthor | Cheol Young Maeng | - |
dc.contributor.affiliatedAuthor | Song Yub Shin | - |
dc.contributor.affiliatedAuthor | Kil Lyong Kim | - |
dc.contributor.affiliatedAuthor | Kyung Soo Hahm | - |
dc.contributor.alternativeName | 이동건 | - |
dc.contributor.alternativeName | Jin | - |
dc.contributor.alternativeName | 맹철영 | - |
dc.contributor.alternativeName | 신송엽 | - |
dc.contributor.alternativeName | 서무열 | - |
dc.contributor.alternativeName | 김길룡 | - |
dc.contributor.alternativeName | 함경수 | - |
dc.identifier.bibliographicCitation | Journal of Microbiology and Biotechnology, vol. 9, no. 2, pp. 168-172 | - |
dc.subject.keyword | Cecropin A | - |
dc.subject.keyword | melittin | - |
dc.subject.keyword | Aspergillus fumigatus | - |
dc.subject.local | Cecropin A | - |
dc.subject.local | cecropin A | - |
dc.subject.local | Melittin | - |
dc.subject.local | melittin | - |
dc.subject.local | Aspergillus fumigatus | - |
dc.description.journalClass | Y | - |
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