Antifungal mechanism of antifungal peptide derived from cecropin A(1-8)-melittin(1-12) hybrid against Aspergillus fumigatus

Cited 0 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorDong Gun Lee-
dc.contributor.authorZhe Zhu Jin-
dc.contributor.authorCheol Young Maeng-
dc.contributor.authorSong Yub Shin-
dc.contributor.authorMoo Yeol Seo-
dc.contributor.authorKil Lyong Kim-
dc.contributor.authorKyung Soo Hahm-
dc.date.accessioned2017-04-19T08:56:09Z-
dc.date.available2017-04-19T08:56:09Z-
dc.date.issued1999-
dc.identifier.issn1017-7825-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4755-
dc.description.abstractThe antifungal mechanism of the antifungal peptide against Aspergillus fumigatus, K18,19CA-(1-8)-ME(1-12), derived from cecropin A(1-8)- melittin(1-12) was investigated by confocal laser scanning microscopy, cell wall regeneration, ATPase activity inhibition, and released potassium ion. By confocal laser scanning microscopy, K18,19-CA(1-8)-ME(1-12) was detected on the surface of A. fumigatus, while cecropin A used as a negative control peptide was not detected. The protoplast of A. fumigatus treated with K18,19-CA(1-8)-ME(1-12) failed to regenerate the fungal cell walls. Compared with cecropin A, the amount of potassium ion released by K18,19-CA(1-8)-ME(1-12) was increased. Furthermore, K18,19-CA(1-8)-ME(1- 12) inhibited the ATPase activity on the plasma membrane. These results suggested that K18,19-CA(1-8)-ME (1-12) acts on the plasma membrane of A. fumigatus and its antifungal action is due to the ion channel or pore formation on the plasma membrane.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleAntifungal mechanism of antifungal peptide derived from cecropin A(1-8)-melittin(1-12) hybrid against Aspergillus fumigatus-
dc.title.alternativeAntifungal mechanism of antifungal peptide derived from cecropin A(1-8)-melittin(1-12) hybrid against Aspergillus fumigatus-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number2-
dc.citation.endPage172-
dc.citation.startPage168-
dc.citation.volume9-
dc.contributor.affiliatedAuthorDong Gun Lee-
dc.contributor.affiliatedAuthorCheol Young Maeng-
dc.contributor.affiliatedAuthorSong Yub Shin-
dc.contributor.affiliatedAuthorKil Lyong Kim-
dc.contributor.affiliatedAuthorKyung Soo Hahm-
dc.contributor.alternativeName이동건-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName맹철영-
dc.contributor.alternativeName신송엽-
dc.contributor.alternativeName서무열-
dc.contributor.alternativeName김길룡-
dc.contributor.alternativeName함경수-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 9, no. 2, pp. 168-172-
dc.subject.keywordCecropin A-
dc.subject.keywordmelittin-
dc.subject.keywordAspergillus fumigatus-
dc.subject.localCecropin A-
dc.subject.localcecropin A-
dc.subject.localMelittin-
dc.subject.localmelittin-
dc.subject.localAspergillus fumigatus-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.