Antitumor effects of IL-6 on murine liver tumor cells in vivo

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dc.contributor.authorHyung Sik Kang-
dc.contributor.authorDae Ho Cho-
dc.contributor.authorSung Sook Kim-
dc.contributor.authorKwang Ho Pyun-
dc.contributor.authorIn Pyo Choi-
dc.date.accessioned2017-04-19T08:56:09Z-
dc.date.available2017-04-19T08:56:09Z-
dc.date.issued1999-
dc.identifier.issn1021-7770-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4757-
dc.description.abstractIL-6 is a pleiotropic cytokine that is capable of modulating the diverse functions of hepatocytes such as acute phase responses and inflammation in the liver. To learn its antitumor effects in vivo, the cDNA of IL-6 was transfected into murine liver cells, TIB cells. IL-6-transfected TIB cells (TIB73-IL-6 or TIB75-IL-6) produced much higher levels of IL-6 compared with vector-transfected TIB cells (TIB73-vec or TIB75-vec). To investigate the effects of IL-6 on TIB tumor growth in vivo, IL-6-transfected TIB cells or vector-transfected TIB cells were injected subcutaneously into syngeneic mice. Vector-transfected TIB cells grew rapidly 3 weeks after injection, but IL-6-transfected TIB cells did not grow at all for up to 6 weeks. Pathologically, IL-6-transfected TIB cells demonstrated a severe necrosis and apoptotic pattern. Taken together, these results indicate that IL-6 functions as a growth inhibiting factor in vivo, and another biological role of IL-6 in the liver is suggested.-
dc.publisherSpringer-BMC-
dc.titleAntitumor effects of IL-6 on murine liver tumor cells in vivo-
dc.title.alternativeAntitumor effects of IL-6 on murine liver tumor cells in vivo-
dc.typeArticle-
dc.citation.titleJournal of Biomedical Science-
dc.citation.number2-
dc.citation.endPage144-
dc.citation.startPage142-
dc.citation.volume6-
dc.contributor.affiliatedAuthorHyung Sik Kang-
dc.contributor.affiliatedAuthorKwang Ho Pyun-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeName강형식-
dc.contributor.alternativeName조대호-
dc.contributor.alternativeName김성숙-
dc.contributor.alternativeName변광호-
dc.contributor.alternativeName최인표-
dc.identifier.bibliographicCitationJournal of Biomedical Science, vol. 6, no. 2, pp. 142-144-
dc.identifier.doi10.1007/BF02256445-
dc.subject.keywordLiver tumor-
dc.subject.keywordInterleukin-6-
dc.subject.keywordAntitumor effects-
dc.subject.keywordHost immunity-
dc.subject.localLiver tumor-
dc.subject.localIL6-
dc.subject.localinterukin -6-
dc.subject.localInterleukin-6 (IL-6)-
dc.subject.localIL-6-
dc.subject.localIl-6-
dc.subject.localinterleukin-6-
dc.subject.localinterleukin-6 (IL-6)-
dc.subject.localInterleukin-6-
dc.subject.localAnti-tumor effects-
dc.subject.localAntitumor effects-
dc.subject.localantitumor effect-
dc.subject.localAnti-tumor effect-
dc.subject.localantitumor effects-
dc.subject.localAntitumor effect-
dc.subject.localHost immunity-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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