MPK38 expression is upregulated in immature T cells activated by concanavalin A

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dc.contributor.authorMin Chan Gil-
dc.contributor.authorYoung Yang-
dc.contributor.authorHyun Jung Ha-
dc.date.accessioned2017-04-19T08:56:13Z-
dc.date.available2017-04-19T08:56:13Z-
dc.date.issued1998-
dc.identifier.issn01652478-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4765-
dc.description.abstractWe have previously identified a cDNA clone from a murine teratocarcinoma PCC4 cDNA library, which we have termed MPK38 for murine protein kinase 38. MPK38 is a new member of the SNF1 serine/threonine kinase family. To understand the role of the MPK38 in thymocytes, we have investigated the level of MPK38 expression by Northern blot analysis. Interestingly, incubation of thymocytes at 37°C resulted in the loss of the MPK38 transcript, however the transcript could be reinduced by treatment with Con A or PHA, but not with PMA and growth factors such as IL-2, IL-7, TGF-β, TNF- α, and EGF. In addition, stimulation of mature T cells from the spleen with Con A failed to reinduce the MPK38 transcript, indicating a developmental regulation of MPK38 expression, whereas non-T cell populations significantly reinduced the transcript. These results suggest that MPK38 may play a functional role as one of the signal regulators in early T cell activation and, potentially, certain lineages of hematopoietic cell activation induced by Con A.-
dc.publisherElsevier-
dc.titleMPK38 expression is upregulated in immature T cells activated by concanavalin A-
dc.title.alternativeMPK38 expression is upregulated in immature T cells activated by concanavalin A-
dc.typeArticle-
dc.citation.titleImmunology Letters-
dc.citation.number0-
dc.citation.endPage83-
dc.citation.startPage79-
dc.citation.volume64-
dc.contributor.alternativeName길민찬-
dc.contributor.alternativeName양영-
dc.contributor.alternativeName하현정-
dc.identifier.bibliographicCitationImmunology Letters, vol. 64, pp. 79-83-
dc.identifier.doi10.1016/S0165-2478(98)00081-9-
dc.subject.keywordThymocytes-
dc.subject.keywordMPK38-
dc.subject.keywordProtein serine/threonine kinase-
dc.subject.keywordT cell activation-
dc.subject.keywordConcanavalin A-
dc.subject.localThymocytes-
dc.subject.localMPK38-
dc.subject.localProtein serine/threonine kinase-
dc.subject.localT cell activation-
dc.subject.localConcanavalin A-
dc.description.journalClassY-
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