Inhibitory activity of monoamine oxidase by coumarins from Peucedanum japonicum

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Title
Inhibitory activity of monoamine oxidase by coumarins from Peucedanum japonicum
Author(s)
Dang Thi Lan Huong; Hee Cheol Choi; Tae Cheol Rho; Hyun Sun Lee; Myung Koo Lee; Young Ho Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 22, no. 3, pp. 324-326
Publication Year
1999
Abstract
Four coumarins were isolated from chloroform extract of the root of Peucedanum japonicum and identified as praeruptorin A (1), xanthotoxin (2), psoralen (3) and bergapten (4) on the basis of spectroscopic methods. The inhibitory activities of these coumarins on monoamine oxidase prepared by mouse brain were tested. The IC50 values of them were shown to be 27.4 μM (1), 40.7 μM (2), 35.8 μM (3), and 13.8 μM (4), in vitro.
Keyword
Peucedanum japonicumUmbelliferaeCoumarinsMonoamine oxidase
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02976373
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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