Inhibition of nitric oxide production by coumarins from Peucedanum Japonicum in LPS-Activated RAW 264.7 cells = 갯기름나물의 쿠마린에 의한 RAW 264.7 세포주의 Nitric oxide 생성 저해활성

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dc.contributor.authorHee Cheol Choi-
dc.contributor.authorTae Cheol Rho-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorHack Ryong Ko-
dc.contributor.authorWon Keun Oh-
dc.contributor.authorChang Keun Seong-
dc.contributor.authorTae Ick Mheen-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorHyun Sun Lee-
dc.date.accessioned2017-04-19T08:56:14Z-
dc.date.available2017-04-19T08:56:14Z-
dc.date.issued1999-
dc.identifier.issn0253-3073-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4772-
dc.description.abstractDuring the screening for inhibitors of nitric oxide production in LPS- activated macrophage, RAW 264.7 cells. Five coumarins were isolated from chloroform extract of the root of Peucedanum japonicum. They were identified as praeruptorin A (1), xanthotoxin (2), psoralen (3), isopimpinellin (4), bergapten (5) on the basis of spectroscopic methods. The IC50 values for nitrite production by activated macrophages were about 1.5 μg/ml (1), 0.3 μg/ml (2), 1.0 μg/ml (3), 25 μg/ml (4), 25 μg/ml (5), respectively. However, the inducible nitric oxide synthase (iNOS) was not inhibited by treatment with these compounds. Their inhibitory effect on nitric oxide production was resulted from the suppression of iNOS expression.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleInhibition of nitric oxide production by coumarins from Peucedanum Japonicum in LPS-Activated RAW 264.7 cells = 갯기름나물의 쿠마린에 의한 RAW 264.7 세포주의 Nitric oxide 생성 저해활성-
dc.title.alternativeInhibition of nitric oxide production by coumarins from Peucedanum Japonicum in LPS-Activated RAW 264.7 cells-
dc.typeArticle-
dc.citation.titleKorean Journal of Pharmacognosy-
dc.citation.number2-
dc.citation.endPage104-
dc.citation.startPage99-
dc.citation.volume30-
dc.contributor.affiliatedAuthorHee Cheol Choi-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorHack Ryong Ko-
dc.contributor.affiliatedAuthorWon Keun Oh-
dc.contributor.affiliatedAuthorTae Ick Mheen-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.alternativeName최희철-
dc.contributor.alternativeName노태철-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName고학룡-
dc.contributor.alternativeName오원근-
dc.contributor.alternativeName성창근-
dc.contributor.alternativeName민태익-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName이현선-
dc.identifier.bibliographicCitationKorean Journal of Pharmacognosy, vol. 30, no. 2, pp. 99-104-
dc.subject.keywordPeucedanum japonicum-
dc.subject.keywordcoumarins-
dc.subject.keywordnitric oxide-
dc.subject.keywordRAW 264.7 cells-
dc.subject.keywordlipopolysaccharide (LPS), iNOS-
dc.subject.localPeucedanum japonicum-
dc.subject.localcoumarin-
dc.subject.localcoumarins-
dc.subject.localCoumarins-
dc.subject.localCoumarin-
dc.subject.localNO-
dc.subject.localnitric oxide-
dc.subject.localnitric oxide (NO)-
dc.subject.localNitric oxide-
dc.subject.localNO (Nitric oxide)-
dc.subject.localnitric oxide.-
dc.subject.localNitric oxid-
dc.subject.localNitric oxide (NO)-
dc.subject.localRAW 264·7 cells-
dc.subject.localRAW 264.7 cells-
dc.subject.locallipopolysaccharide (LPS), iNOS-
dc.description.journalClassN-
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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