Effects of Lactic acid bacteria on infection of Salmonella typhimurium in mouse = 유산균 투여가 마우스의 Salmonella균 감염에 미치는 영향

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Effects of Lactic acid bacteria on infection of Salmonella typhimurium in mouse = 유산균 투여가 마우스의 Salmonella균 감염에 미치는 영향
H S Jun; Yang Kyu Choi; Young Suk Won; Byung Hwa Hyun; J W Kim
Bibliographic Citation
Korean Journal of Dairy Science, vol. 21, no. 2, pp. 171-182
Publication Year
This study was performed to find out the protective effects of lactic acid bacteria against the infection of Salmonella typhimurium in ICR mice. The experimental mice were divided into 5 groups. A control group was orally administered with 0.2㎖ of saline, and other 4 groups, with Lact. acidophilus(LA; A group), Lact. casei(LC; B group), the mixture of LA and LC(C group) and the mixture of Lact. bulgaricus and Strept. thermophilus(D group) at 5×10^9CFU/0.2㎖ for 7 days, then challenged with Salmonella typhimurium at 4×10^7CFU/0.2㎖. Body weight gains, relative spleen weights, peripheral leucocytes, the lesion scores of the liver and spleen, and the recovery rate of Salmonella typhimurium from the liver and spleen were invetigated. Furthermore, the total IgA concentration in the serum and intestinal fluid for the experimental groups were measured by using ELISA test. 1. The mice in the groups fed with lactic acid bacteria showed higher body weight gains than the control group during the 6th to 10th days after challenged with Sal. typhimurium. 2. When the relative spleen weights(%) were measured after challenge, the groups fed with lactic acid bacteria revealed higher value than the control group. Among the experimental groups, the highest value was detected in A group, but the lowest value in D group. 3. In measuring the changes of peripheral leucocytes, the highest total leucocyte counts were observed in A group, and the increasing tendency of the number of lymphocytes was detected in B and C groups. The number of neutrophils were found increased in all of the experimental groups. 4. When the lesion scores were examined by the white spots in the liver and spleen of the mice, A group showed the highest value of the experimental groups, followed in order of D and C groups. The lowest value was detected with the mice in B group. In the recovery test of the viable Sal. typhimurium from the liver and spleen, B and C groups demonstrate significantly lower recovery rate as compared with those of A and control groups(p<0.05). 5. In measuring the total IgA concentration in the intestinal fluid by ELISA, the highest value were observed in the group B on the 2nd days post-challenge. At the 4th to 8th days post-challenge, the value appeared higher in C and D groups. No significant differences among the groups were found in the case of serum.
Lactic acid bacteriaSalmonella typhimuriumIgAELISA
Korea Soc-Assoc-Inst
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Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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