Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats

Cited 65 time in scopus
Metadata Downloads
Title
Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats
Author(s)
Yong Won Shin; Song Hae Bok; Tae Sook Jeong; Ki Hwan Bae; Nam Ho Jeoung; Myung Sook Choi; Sung Heui Lee; Yong Bok Park
Bibliographic Citation
International Journal for Vitamin and Nutrition Research, vol. 69, no. 5, pp. 341-347
Publication Year
1999
Abstract
The effects of the citrus bioflavonoid naringin were tested by using it as a supplement in a high-cholesterol diet. Male rats were fed for 42 days with a 1% (wt/wt) high cholesterol diet either with or without naringin-supplementation (0.1%, wt/wt) to study the effect on plasma lipid levels, hepatic lipid contents, hepatic enzyme activity, and the excretion of fecal neutral sterols. Naringin did not significantly alter the levels of plasma triglycerides, however, the levels of plasma cholesterol (3.80 ± 0.31 mmol/L vs. 2.61 ± 0.30 mmol/L, mean ± SE; p < 0.05) and hepatic cholesterol (70.3 ± 4.3 mg/g vs. 54.3 ± 3.8 mg/g, mean ± SD; p < 0.05) were significantly lowered compared to those of the control. HMG-CoA reductase (2487.0 ± 210.0 pmole/min/mg vs. 1879.0 ± 236.0 pmole/min/mg, mean ± SE; p < 0.05) and ACAT (806.0 ± 105.0 pmole/min/mg vs. 643.0 ± 80.0 pmole/min/mg, mean ± SE; p < 0.05) activities were both substantially lower in the naringin-supplemented group than in the control. The naringin supplementation markedly decreased the excretion of fecal neutral sterols (204.7 ± 28.5 mg/day) compared to the control (521.9 ± 53.9 mg/day). The combination of the inhibited HMG-CoA reductase (-24.4%) and ACAT (-20.2%) activities as a result of naringin supplementation could account for the decrease of fecal neutral sterols.
Keyword
ACATHMG-CoA reductasecholesterol-lowering effect
ISSN
0300-9831
Publisher
Verlag Hans Huber
DOI
http://dx.doi.org/10.1024/0300-9831.69.5.341
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.