Protective antitumor activity through dendritic cell immunization is mediated by NK cell as well as CTL activation

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dc.contributor.authorKwang Dong Kim-
dc.contributor.authorJin Koo Kim-
dc.contributor.authorSe Jin Kim-
dc.contributor.authorIn Seong Choe-
dc.contributor.authorTai Wha Chung-
dc.contributor.authorYong Kyung Choe-
dc.contributor.authorJong-Seok Lim-
dc.date.accessioned2017-04-19T08:56:18Z-
dc.date.available2017-04-19T08:56:18Z-
dc.date.issued1999-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4796-
dc.description.abstractDendritic cells (DCs) are potent professional antigen-presenting cells (APC) capable of inducing the primary T cell response to antigen. Although tumor cells express target antigens, they are incapable of stimulating a tumor-specific immune response due to a defect in the costimulatory signal that is required for optimal activation of T cells. In this work, we describe a new approach using tumor-DC coculture to improve the antigen presenting capacity of tumor cells, which does not require a source of tumor-associated antigen. Immunization of a weakly immunogenic and progressive tumor cocultured with bone marrow-derived DCs generated an effective tumor vaccine. Immunization with the cocultured DCs was able to induce complete protective immunity against tumor challenges and was effective for the induction of tumor-specific CTL (cytotoxic T lymphocyte) activity. Furthermore, high NK cell activity was observed in mice in which tumors were rejected. In addition, immunization with tumor-pulsed DCs induced delayed tumor growth, but not tumor eradication in tumor-bearing mice. Our results demonstrate that coculture of DCs with tumors generated antitumor immunity due to the NK cell activation as well as tumor-specific T cell. This approach would be useful for designing tumor vaccines using DCs when the information about tumor antigens is limited.-
dc.publisherPharmaceutical Soc Korea-
dc.titleProtective antitumor activity through dendritic cell immunization is mediated by NK cell as well as CTL activation-
dc.title.alternativeProtective antitumor activity through dendritic cell immunization is mediated by NK cell as well as CTL activation-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number4-
dc.citation.endPage347-
dc.citation.startPage340-
dc.citation.volume22-
dc.contributor.affiliatedAuthorKwang Dong Kim-
dc.contributor.affiliatedAuthorJin Koo Kim-
dc.contributor.affiliatedAuthorSe Jin Kim-
dc.contributor.affiliatedAuthorIn Seong Choe-
dc.contributor.affiliatedAuthorTai Wha Chung-
dc.contributor.affiliatedAuthorYong Kyung Choe-
dc.contributor.affiliatedAuthorJong-Seok Lim-
dc.contributor.alternativeName김광동-
dc.contributor.alternativeName김진구-
dc.contributor.alternativeName김세진-
dc.contributor.alternativeName최인성-
dc.contributor.alternativeName정태화-
dc.contributor.alternativeName최용경-
dc.contributor.alternativeName임종석-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 22, no. 4, pp. 340-347-
dc.identifier.doi10.1007/BF02979055-
dc.subject.keywordDendritic cells (DCs)-
dc.subject.keywordColon tumor-
dc.subject.keywordAntitumor immunity-
dc.subject.localdendritic cell-
dc.subject.localdendritic cells-
dc.subject.localdendritic cells (DC)-
dc.subject.localDendritic cell-
dc.subject.localDendritic cells-
dc.subject.localDendritic cells (DC)-
dc.subject.localDendritic cells (DCs)-
dc.subject.localColon tumor-
dc.subject.localAntitumor immunity-
dc.subject.localAnti-tumor immunity-
dc.description.journalClassY-
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