DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwang Dong Kim | - |
dc.contributor.author | Jin Koo Kim | - |
dc.contributor.author | Se Jin Kim | - |
dc.contributor.author | In Seong Choe | - |
dc.contributor.author | Tai Wha Chung | - |
dc.contributor.author | Yong Kyung Choe | - |
dc.contributor.author | Jong-Seok Lim | - |
dc.date.accessioned | 2017-04-19T08:56:18Z | - |
dc.date.available | 2017-04-19T08:56:18Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/4796 | - |
dc.description.abstract | Dendritic cells (DCs) are potent professional antigen-presenting cells (APC) capable of inducing the primary T cell response to antigen. Although tumor cells express target antigens, they are incapable of stimulating a tumor-specific immune response due to a defect in the costimulatory signal that is required for optimal activation of T cells. In this work, we describe a new approach using tumor-DC coculture to improve the antigen presenting capacity of tumor cells, which does not require a source of tumor-associated antigen. Immunization of a weakly immunogenic and progressive tumor cocultured with bone marrow-derived DCs generated an effective tumor vaccine. Immunization with the cocultured DCs was able to induce complete protective immunity against tumor challenges and was effective for the induction of tumor-specific CTL (cytotoxic T lymphocyte) activity. Furthermore, high NK cell activity was observed in mice in which tumors were rejected. In addition, immunization with tumor-pulsed DCs induced delayed tumor growth, but not tumor eradication in tumor-bearing mice. Our results demonstrate that coculture of DCs with tumors generated antitumor immunity due to the NK cell activation as well as tumor-specific T cell. This approach would be useful for designing tumor vaccines using DCs when the information about tumor antigens is limited. | - |
dc.publisher | Pharmaceutical Soc Korea | - |
dc.title | Protective antitumor activity through dendritic cell immunization is mediated by NK cell as well as CTL activation | - |
dc.title.alternative | Protective antitumor activity through dendritic cell immunization is mediated by NK cell as well as CTL activation | - |
dc.type | Article | - |
dc.citation.title | Archives of Pharmacal Research | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 347 | - |
dc.citation.startPage | 340 | - |
dc.citation.volume | 22 | - |
dc.contributor.affiliatedAuthor | Kwang Dong Kim | - |
dc.contributor.affiliatedAuthor | Jin Koo Kim | - |
dc.contributor.affiliatedAuthor | Se Jin Kim | - |
dc.contributor.affiliatedAuthor | In Seong Choe | - |
dc.contributor.affiliatedAuthor | Tai Wha Chung | - |
dc.contributor.affiliatedAuthor | Yong Kyung Choe | - |
dc.contributor.affiliatedAuthor | Jong-Seok Lim | - |
dc.contributor.alternativeName | 김광동 | - |
dc.contributor.alternativeName | 김진구 | - |
dc.contributor.alternativeName | 김세진 | - |
dc.contributor.alternativeName | 최인성 | - |
dc.contributor.alternativeName | 정태화 | - |
dc.contributor.alternativeName | 최용경 | - |
dc.contributor.alternativeName | 임종석 | - |
dc.identifier.bibliographicCitation | Archives of Pharmacal Research, vol. 22, no. 4, pp. 340-347 | - |
dc.identifier.doi | 10.1007/BF02979055 | - |
dc.subject.keyword | Dendritic cells (DCs) | - |
dc.subject.keyword | Colon tumor | - |
dc.subject.keyword | Antitumor immunity | - |
dc.subject.local | dendritic cell | - |
dc.subject.local | dendritic cells | - |
dc.subject.local | dendritic cells (DC) | - |
dc.subject.local | Dendritic cell | - |
dc.subject.local | Dendritic cells | - |
dc.subject.local | Dendritic cells (DC) | - |
dc.subject.local | Dendritic cells (DCs) | - |
dc.subject.local | Colon tumor | - |
dc.subject.local | Antitumor immunity | - |
dc.subject.local | Anti-tumor immunity | - |
dc.description.journalClass | Y | - |
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