A novel angiotensin-I-converting enzyme inhibitory peptide from human αs₁-casein

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Title
A novel angiotensin-I-converting enzyme inhibitory peptide from human αs₁-casein
Author(s)
Yoo Kyeong Kim; Bong Hyun Chung
Bibliographic Citation
Biotechnology Letters, vol. 21, pp. 575-578
Publication Year
1999
Abstract
We have previously reported three novel angiotensin-I-converting enzyme (ACE) inhibitory peptides, Tyr-Pro-Glu-Arg, Tyr-Tyr-Pro-Gln-Ile-Met-Gln-Tyr and Asn-Asn-Val-Met-Leu-Gln-Trp, isolated from the tryptic digest of recombinant human α(s1)-casein. A series of C-terminal di- and tripeptides from these three peptides have now been synthesized and their ACE inhibitory activities have been measured. Among the peptides tested, the tripeptide Leu-Gln-Trp had the highest ACE inhibitory activity (IC50 = 3.8 μmol l-1).
Keyword
ACE inhibitory peptidehuman α(s1)-caseinLeu-Gln-Trp
ISSN
0141-5492
Publisher
Springer
DOI
http://dx.doi.org/10.1023/A:1005572504196
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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