Phospholipase Cγ1 inhibitory principles from the sarcotestas of Ginkgo biloba (2) = 은행 종의의 Phospholipase Cγ1 저해 활성 성분 (2)

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Title
Phospholipase Cγ1 inhibitory principles from the sarcotestas of Ginkgo biloba (2) = 은행 종의의 Phospholipase Cγ1 저해 활성 성분 (2)
Author(s)
Ji Suk Lee; You Sun Cho; Jin Woong Kim; Hyun Sun LeeJong Seog Ahn
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 30, no. 3, pp. 280-283
Publication Year
1999
Abstract
Using the bioassay-guided fractionation and isolation technique, two PLCγ1 inhibitors were isolated from the sarcotestas of Ginkgo biloba (Ginkgoaceae). The structures of these compounds were identified as (3R)-(-)- 8-hydroxy-3-(6'-pentadecenyl)-3,4-dihydroisocoumarin (1) and 3-heptadecen-2- one (2) by UV, IR, MS, 1H-NMR and H-13C COSY. Isolated compounds 1 and 2 have not been reported previously from the sarcotestas of G. biloba and Ginkgoaceae, respectively. In addition, these compounds showed significant PLCγ1 inhibitory effects with the IC50 of the 9.7 (1) and 25.6 μM (2).
ISSN
0253-3073
Publisher
South Korea
DOI
http://dx.doi.org/10.1021/np970367q
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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