Antibacterial activity of antimycotic miconazole against methicillin-resistant Staphylococcus aureus

Abstract

Miconazole was estimated to have a minimum inhibitory concentration of 0.78 μg/ml against the methicillin-resistant strains of Staphylococcus aureus (MRSA). The antibacterial activity of miconazole against MRSA was bacteriostatic in cation-adjusted Mueller-Hinton broth, but bacteriocidal in saline solution. The anti-MRSA activity of miconazole did not show a significant change under the susceptibility-testing conditions such as various inoculum sizes, pHs, or cations (Ca++ or Mg++) which was added to the medium. However, the anti-MRSA activity of miconazole was completely suppressed by lipophilic α-tocopherol (50 μg/ml), but definitely not by water-soluble ascorbic acid.